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Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Author

Listed:
  • Ana Latorre-Pellicer

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III
    Grupo de Medicina Xenómica, CIBERER, Universidad de Santiago de Compostela)

  • Raquel Moreno-Loshuertos

    (Universidad de Zaragoza)

  • Ana Victoria Lechuga-Vieco

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III
    CIBERES, C/ Melchor Fernández-Almagro 3)

  • Fátima Sánchez-Cabo

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Carlos Torroja

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Rebeca Acín-Pérez

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Enrique Calvo

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Esther Aix

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Andrés González-Guerra

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Angela Logan

    (Medical Research Council Mitochondrial Biology Unit)

  • María Luisa Bernad-Miana

    (SAI de Biomedicina y Biomateriales & Phenotypic Unit, Instituto Aragonés de Ciencias de la salud)

  • Eduardo Romanos

    (SAI de Biomedicina y Biomateriales & Phenotypic Unit, Instituto Aragonés de Ciencias de la salud)

  • Raquel Cruz

    (Grupo de Medicina Xenómica, CIBERER, Universidad de Santiago de Compostela)

  • Sara Cogliati

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Beatriz Sobrino

    (Fundación Pública Gallega Medicina Xenómica, SERGAS, Complexo Hospitalario Universitario de Santiago)

  • Ángel Carracedo

    (Grupo de Medicina Xenómica, CIBERER, Universidad de Santiago de Compostela
    Fundación Pública Gallega Medicina Xenómica, SERGAS, Complexo Hospitalario Universitario de Santiago
    Center of Excellence in Genomic Medicine Research, King Abdulaziz University)

  • Acisclo Pérez-Martos

    (Universidad de Zaragoza)

  • Patricio Fernández-Silva

    (Universidad de Zaragoza)

  • Jesús Ruíz-Cabello

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III
    CIBERES, C/ Melchor Fernández-Almagro 3
    Universidad Complutense de Madrid)

  • Michael P. Murphy

    (Medical Research Council Mitochondrial Biology Unit)

  • Ignacio Flores

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • Jesús Vázquez

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III)

  • José Antonio Enríquez

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III
    Universidad de Zaragoza)

Abstract

Conplastic mice that share the same nuclear genome but have different mitochondrial DNA were analysed throughout their life — the mitochondrial genome affects many aspects of physiology and results in differences in median lifespan; the authors propose that the interplay of mitochondrial and nuclear genomes may be an important factor influencing this phenomenon.

Suggested Citation

  • Ana Latorre-Pellicer & Raquel Moreno-Loshuertos & Ana Victoria Lechuga-Vieco & Fátima Sánchez-Cabo & Carlos Torroja & Rebeca Acín-Pérez & Enrique Calvo & Esther Aix & Andrés González-Guerra & Angela L, 2016. "Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing," Nature, Nature, vol. 535(7613), pages 561-565, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18618
    DOI: 10.1038/nature18618
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    Cited by:

    1. Luis Filipe Costa-Machado & Esther Garcia-Dominguez & Rebecca L. McIntyre & Jose Luis Lopez-Aceituno & Álvaro Ballesteros-Gonzalez & Andrea Tapia-Gonzalez & David Fabregat-Safont & Tobias Eisenberg & , 2023. "Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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