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Structural organization of the inactive X chromosome in the mouse

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  • Luca Giorgetti

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
    †Present address: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.)

  • Bryan R. Lajoie

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Ava C. Carter

    (Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine)

  • Mikael Attia

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934)

  • Ye Zhan

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Jin Xu

    (Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine)

  • Chong Jian Chen

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934)

  • Noam Kaplan

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Howard Y. Chang

    (Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine)

  • Edith Heard

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
    Collège de France)

  • Job Dekker

    (Program in Systems Biology, University of Massachusetts Medical School
    Howard Hughes Medical Institute, University of Massachusetts Medical School)

Abstract

An in-depth analysis of the structure, chromatin accessibility and expression status of the mouse inactive X (Xi) chromosome provides insights into the regulation of Xi chromosome structure, its dependence on the macrosatellite DXZ4 region, the Xist non-coding RNA, as well as the basis for topologically associating domain (TAD) formation on the Xi.

Suggested Citation

  • Luca Giorgetti & Bryan R. Lajoie & Ava C. Carter & Mikael Attia & Ye Zhan & Jin Xu & Chong Jian Chen & Noam Kaplan & Howard Y. Chang & Edith Heard & Job Dekker, 2016. "Structural organization of the inactive X chromosome in the mouse," Nature, Nature, vol. 535(7613), pages 575-579, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18589
    DOI: 10.1038/nature18589
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    Cited by:

    1. Antonio Lentini & Huaitao Cheng & J. C. Noble & Natali Papanicolaou & Christos Coucoravas & Nathanael Andrews & Qiaolin Deng & Martin Enge & Björn Reinius, 2022. "Elastic dosage compensation by X-chromosome upregulation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Andrew Keniry & Natasha Jansz & Linden J. Gearing & Iromi Wanigasuriya & Joseph Chen & Christian M. Nefzger & Peter F. Hickey & Quentin Gouil & Joy Liu & Kelsey A. Breslin & Megan Iminitoff & Tamara B, 2022. "BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Mayank N. K. Choudhary & Kara Quaid & Xiaoyun Xing & Heather Schmidt & Ting Wang, 2023. "Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Sandhya Chandrasekaran & Sergio Espeso-Gil & Yong-Hwee Eddie Loh & Behnam Javidfar & Bibi Kassim & Yueyan Zhu & Yuan Zhang & Yuhao Dong & Lucy K. Bicks & Haixin Li & Prashanth Rajarajan & Cyril J. Pet, 2021. "Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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