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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

Author

Listed:
  • Anthony J. Filiano

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Yang Xu

    (University of Massachusetts Medical School)

  • Nicholas J. Tustison

    (School of Medicine, University of Virginia)

  • Rachel L. Marsh

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Wendy Baker

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Igor Smirnov

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Christopher C. Overall

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Sachin P. Gadani

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia
    Neuroscience Graduate Program, School of Medicine, University of Virginia
    Medical Scientist Training Program, School of Medicine, University of Virginia)

  • Stephen D. Turner

    (School of Medicine University of Virginia)

  • Zhiping Weng

    (University of Massachusetts Medical School)

  • Sayeda Najamussahar Peerzade

    (University of Massachusetts Medical School)

  • Hao Chen

    (University of Massachusetts Medical School)

  • Kevin S. Lee

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia
    Neuroscience Graduate Program, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Michael M. Scott

    (Neuroscience Graduate Program, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Mark P. Beenhakker

    (Neuroscience Graduate Program, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Vladimir Litvak

    (University of Massachusetts Medical School)

  • Jonathan Kipnis

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia
    Neuroscience Graduate Program, School of Medicine, University of Virginia
    Medical Scientist Training Program, School of Medicine, University of Virginia)

Abstract

Adaptive immune dysfunction, in particular interferon-γ, is implicated in disorders characterized by social dysfunction and suggests interferon-γ signalling may provide a co-evolutionary link between social behaviour and an anti-pathogen immune response.

Suggested Citation

  • Anthony J. Filiano & Yang Xu & Nicholas J. Tustison & Rachel L. Marsh & Wendy Baker & Igor Smirnov & Christopher C. Overall & Sachin P. Gadani & Stephen D. Turner & Zhiping Weng & Sayeda Najamussahar , 2016. "Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour," Nature, Nature, vol. 535(7612), pages 425-429, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7612:d:10.1038_nature18626
    DOI: 10.1038/nature18626
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    Cited by:

    1. Stefano Garofalo & Germana Cocozza & Alessandro Mormino & Giovanni Bernardini & Eleonora Russo & Donald Ielpo & Diego Andolina & Rossella Ventura & Katiuscia Martinello & Massimiliano Renzi & Sergio F, 2023. "Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Randall H. Friedline & Hye Lim Noh & Sujin Suk & Mahaa Albusharif & Sezin Dagdeviren & Suchaorn Saengnipanthkul & Bukyung Kim & Allison M. Kim & Lauren H. Kim & Lauren A. Tauer & Natalie M. Baez Torre, 2024. "IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Marius Schwabenland & Omar Mossad & Annika Sievert & Adam G. Peres & Elena Ringel & Sebastian Baasch & Julia Kolter & Giulia Cascone & Nikolaos Dokalis & Andreas Vlachos & Zsolt Ruzsics & Philipp Henn, 2023. "Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. Stefano Suzzi & Tommaso Croese & Adi Ravid & Or Gold & Abbe R. Clark & Sedi Medina & Daniel Kitsberg & Miriam Adam & Katherine A. Vernon & Eva Kohnert & Inbar Shapira & Sergey Malitsky & Maxim Itkin &, 2023. "N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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