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Identification of proliferative and mature β-cells in the islets of Langerhans

Author

Listed:
  • Erik Bader

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
    Institute of Stem Cell Research, Helmholtz Zentrum München
    Institute of Epidemiology II, Helmholtz Zentrum München)

  • Adriana Migliorini

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
    Institute of Stem Cell Research, Helmholtz Zentrum München)

  • Moritz Gegg

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
    Institute of Stem Cell Research, Helmholtz Zentrum München)

  • Noah Moruzzi

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
    Karolinska University Hospital)

  • Jantje Gerdes

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München)

  • Sara S. Roscioni

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München)

  • Mostafa Bakhti

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München)

  • Elisabeth Brandl

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München)

  • Martin Irmler

    (German Center for Diabetes Research (DZD)
    Institute of Experimental Genetics, Helmholtz Zentrum München)

  • Johannes Beckers

    (German Center for Diabetes Research (DZD)
    Institute of Experimental Genetics, Helmholtz Zentrum München
    Technische Universität München)

  • Michaela Aichler

    (Research Unit Analytical Pathology, Helmholtz Zentrum München)

  • Annette Feuchtinger

    (Research Unit Analytical Pathology, Helmholtz Zentrum München)

  • Christin Leitzinger

    (Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München)

  • Hans Zischka

    (Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München)

  • Rui Wang-Sattler

    (Institute of Epidemiology II, Helmholtz Zentrum München)

  • Martin Jastroch

    (German Center for Diabetes Research (DZD)
    Institute of Diabetes and Obesity, Helmholtz Zentrum München)

  • Matthias Tschöp

    (German Center for Diabetes Research (DZD)
    Institute of Diabetes and Obesity, Helmholtz Zentrum München)

  • Fausto Machicao

    (German Center for Diabetes Research (DZD)
    Institute for Diabetes Research and Metabolic Diseases, Helmholtz Zentrum München, University of Tübingen)

  • Harald Staiger

    (German Center for Diabetes Research (DZD)
    Institute for Diabetes Research and Metabolic Diseases, Helmholtz Zentrum München, University of Tübingen
    Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen)

  • Hans-Ulrich Häring

    (German Center for Diabetes Research (DZD)
    Institute for Diabetes Research and Metabolic Diseases, Helmholtz Zentrum München, University of Tübingen
    Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen)

  • Helena Chmelova

    (German Center for Diabetes Research (DZD)
    Paul Langerhans Institute Dresden (PLID), Helmholtz Zentrum München, University Clinic Carl Gustav Carus, Technische Universität Dresden
    DFG-Center for Regenerative Therapies Dresden (CRTD), Faculty of Medicine, Technische Universität)

  • Julie A. Chouinard

    (German Center for Diabetes Research (DZD)
    Paul Langerhans Institute Dresden (PLID), Helmholtz Zentrum München, University Clinic Carl Gustav Carus, Technische Universität Dresden
    DFG-Center for Regenerative Therapies Dresden (CRTD), Faculty of Medicine, Technische Universität)

  • Nikolay Oskolkov

    (Diabetes and Endocrinology, Lund University Diabetes Centre)

  • Olle Korsgren

    (Genetics and Pathology, Uppsala University)

  • Stephan Speier

    (German Center for Diabetes Research (DZD)
    Paul Langerhans Institute Dresden (PLID), Helmholtz Zentrum München, University Clinic Carl Gustav Carus, Technische Universität Dresden
    DFG-Center for Regenerative Therapies Dresden (CRTD), Faculty of Medicine, Technische Universität)

  • Heiko Lickert

    (Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
    Institute of Stem Cell Research, Helmholtz Zentrum München
    German Center for Diabetes Research (DZD)
    Technische Universität München)

Abstract

Mature pancreatic β-cells can be distinguished from proliferating ones by expression of the Fltp reporter gene, which is triggered by Wnt signalling and β-cell polarization and islet compaction.

Suggested Citation

  • Erik Bader & Adriana Migliorini & Moritz Gegg & Noah Moruzzi & Jantje Gerdes & Sara S. Roscioni & Mostafa Bakhti & Elisabeth Brandl & Martin Irmler & Johannes Beckers & Michaela Aichler & Annette Feuc, 2016. "Identification of proliferative and mature β-cells in the islets of Langerhans," Nature, Nature, vol. 535(7612), pages 430-434, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7612:d:10.1038_nature18624
    DOI: 10.1038/nature18624
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