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The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA

Author

Listed:
  • Jeremy G. Bird

    (Rutgers University
    Rutgers University)

  • Yu Zhang

    (Rutgers University)

  • Yuan Tian

    (Rutgers University)

  • Natalya Panova

    (Institute of Microbiology, Czech Academy of Sciences, v.v.i., Vídenˇ ská 1083)

  • Ivan Barvík

    (Institute of Physics, Faculty of Mathematics and Physics, Charles University in Prague)

  • Landon Greene

    (Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, One Squibb Drive)

  • Min Liu

    (Environmental and Occupational Health Sciences Institute, Rutgers University)

  • Brian Buckley

    (Environmental and Occupational Health Sciences Institute, Rutgers University)

  • Libor Krásný

    (Institute of Microbiology, Czech Academy of Sciences, v.v.i., Vídenˇ ská 1083)

  • Jeehiun K. Lee

    (Rutgers University)

  • Craig D. Kaplan

    (Texas A&M University)

  • Richard H. Ebright

    (Rutgers University)

  • Bryce E. Nickels

    (Rutgers University)

Abstract

RNA caps other than the 7-methylguanylate modification are generated by a distinct mechanism in which caps are added during, not after, transcription initiation through the use of non-canonical initiating nucleotides by RNA polymerases, a finding which has functional consequences.

Suggested Citation

  • Jeremy G. Bird & Yu Zhang & Yuan Tian & Natalya Panova & Ivan Barvík & Landon Greene & Min Liu & Brian Buckley & Libor Krásný & Jeehiun K. Lee & Craig D. Kaplan & Richard H. Ebright & Bryce E. Nickels, 2016. "The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA," Nature, Nature, vol. 535(7612), pages 444-447, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7612:d:10.1038_nature18622
    DOI: 10.1038/nature18622
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    Cited by:

    1. Sunny Sharma & Jun Yang & Ewa Grudzien-Nogalska & Jessica Shivas & Kelvin Y. Kwan & Megerditch Kiledjian, 2022. "Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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