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Resolving early mesoderm diversification through single-cell expression profiling

Author

Listed:
  • Antonio Scialdone

    (EMBL-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
    Wellcome Trust Sanger Institute)

  • Yosuke Tanaka

    (Cambridge Institute for Medical Research, University of Cambridge
    Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge
    †Present address: Division of Cellular Therapy, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.)

  • Wajid Jawaid

    (Cambridge Institute for Medical Research, University of Cambridge
    Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge)

  • Victoria Moignard

    (Cambridge Institute for Medical Research, University of Cambridge
    Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge)

  • Nicola K. Wilson

    (Cambridge Institute for Medical Research, University of Cambridge
    Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge)

  • Iain C. Macaulay

    (Wellcome Trust Sanger Institute)

  • John C. Marioni

    (EMBL-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
    Wellcome Trust Sanger Institute
    Cancer Research UK Cambridge Institute, University of Cambridge)

  • Berthold Göttgens

    (Cambridge Institute for Medical Research, University of Cambridge
    Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge)

Abstract

Analysis of the transcriptome of more than 1,200 cells from gastrulating mouse embryos using single-cell sequencing, gathering unexpected insights into early mesoderm formation during gastrulation.

Suggested Citation

  • Antonio Scialdone & Yosuke Tanaka & Wajid Jawaid & Victoria Moignard & Nicola K. Wilson & Iain C. Macaulay & John C. Marioni & Berthold Göttgens, 2016. "Resolving early mesoderm diversification through single-cell expression profiling," Nature, Nature, vol. 535(7611), pages 289-293, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7611:d:10.1038_nature18633
    DOI: 10.1038/nature18633
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    Cited by:

    1. Karin D. Prummel & Helena L. Crowell & Susan Nieuwenhuize & Eline C. Brombacher & Stephan Daetwyler & Charlotte Soneson & Jelena Kresoja-Rakic & Agnese Kocere & Manuel Ronner & Alexander Ernst & Zahra, 2022. "Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Ran Wang & Xianfa Yang & Jiehui Chen & Lin Zhang & Jonathan A. Griffiths & Guizhong Cui & Yingying Chen & Yun Qian & Guangdun Peng & Jinsong Li & Liantang Wang & John C. Marioni & Patrick P. L. Tam & , 2023. "Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. C. Biben & T. S. Weber & K. S. Potts & J. Choi & D. C. Miles & A. Carmagnac & T. Sargeant & C. A. Graaf & K. A. Fennell & A. Farley & O. J. Stonehouse & M. A. Dawson & D. J. Hilton & S. H. Naik & S. T, 2023. "In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Qi Liu & Charles A Herring & Quanhu Sheng & Jie Ping & Alan J Simmons & Bob Chen & Amrita Banerjee & Wei Li & Guoqiang Gu & Robert J Coffey & Yu Shyr & Ken S Lau, 2018. "Quantitative assessment of cell population diversity in single-cell landscapes," PLOS Biology, Public Library of Science, vol. 16(10), pages 1-29, October.

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