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TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis

Author

Listed:
  • Joanne Hsieh

    (Columbia University)

  • Masahiro Koseki

    (Columbia University
    Cardiovascular Medicine, Osaka University Graduate School of Medicine)

  • Matthew M. Molusky

    (Columbia University)

  • Emi Yakushiji

    (Columbia University)

  • Ikuyo Ichi

    (Faculty of Core Research, Ochanomizu University)

  • Marit Westerterp

    (Columbia University)

  • Jahangir Iqbal

    (State University of New York Health Science Center at Brooklyn (SUNY Downstate Medical Center))

  • Robin B. Chan

    (Columbia University)

  • Sandra Abramowicz

    (Columbia University)

  • Liana Tascau

    (Columbia University)

  • Shunichi Takiguchi

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Shizuya Yamashita

    (Cardiovascular Medicine, Osaka University Graduate School of Medicine)

  • Carrie L. Welch

    (Columbia University)

  • Gilbert Di Paolo

    (Columbia University)

  • M. Mahmood Hussain

    (State University of New York Health Science Center at Brooklyn (SUNY Downstate Medical Center))

  • Jay H. Lefkowitch

    (Columbia University)

  • Daniel J. Rader

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Alan R. Tall

    (Columbia University)

Abstract

In mice, deficiency in the high-density lipoprotein gene T39 stabilizes liver X receptor (LXR), reducing both atherosclerosis and steatohepatitis, suggesting that T39 inhibition could be an effective strategy for reducing these diseases.

Suggested Citation

  • Joanne Hsieh & Masahiro Koseki & Matthew M. Molusky & Emi Yakushiji & Ikuyo Ichi & Marit Westerterp & Jahangir Iqbal & Robin B. Chan & Sandra Abramowicz & Liana Tascau & Shunichi Takiguchi & Shizuya Y, 2016. "TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis," Nature, Nature, vol. 535(7611), pages 303-307, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7611:d:10.1038_nature18628
    DOI: 10.1038/nature18628
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