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Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

Author

Listed:
  • Sven Reischauer

    (University of California San Francisco
    Max Planck Institute for Heart and Lung Research)

  • Oliver A. Stone

    (University of California San Francisco
    Max Planck Institute for Heart and Lung Research)

  • Alethia Villasenor

    (University of California San Francisco
    Max Planck Institute for Heart and Lung Research)

  • Neil Chi

    (University of California San Francisco
    Institute of Genomic Medicine, University of California San Diego)

  • Suk-Won Jin

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Marcel Martin

    (Science for Life Laboratory, Stockholm University)

  • Miler T. Lee

    (Yale University School of Medicine
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Nana Fukuda

    (Max Planck Institute for Heart and Lung Research)

  • Michele Marass

    (Max Planck Institute for Heart and Lung Research)

  • Alec Witty

    (Institute of Genomic Medicine, University of California San Diego)

  • Ian Fiddes

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Taiyi Kuo

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Won-Suk Chung

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Sherveen Salek

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Robert Lerrigo

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Jessica Alsiö

    (University of California San Francisco
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Shujun Luo

    (Illumina
    †Present addresses: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA (S.-W.J.); Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA (M.T.L.); Genomics Institute, University of California Santa Cruz and Howard Hughes Medical Institute, Santa Cruz, California 95064, USA (I.F.); Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA (T.K.); Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea (W.-S.C.); Johns Hopkins Hospital, Wilmer Eye Institute, Baltimore, Maryland 21224, USA (S.S.); Division of General Internal Medicine, University of Washington, Seattle, Washington 98104, USA (R.L.); Novartis, Basel 4056, Switzerland (J.A.); Personalis, Menlo Park, California 94025, USA (S.L.).)

  • Dominika Tworus

    (Karolinska Institutet)

  • Sruthy M. Augustine

    (Max Planck Institute for Heart and Lung Research)

  • Sophie Mucenieks

    (Max Planck Institute for Heart and Lung Research)

  • Björn Nystedt

    (Science for Life Laboratory, Uppsala University)

  • Antonio J. Giraldez

    (Yale University School of Medicine)

  • Gary P. Schroth

    (Illumina)

  • Olov Andersson

    (Karolinska Institutet)

  • Didier Y. R. Stainier

    (University of California San Francisco
    Max Planck Institute for Heart and Lung Research)

Abstract

The zebrafish cloche gene is required for the formation of most endothelial and haematopoietic cells, however, it has been difficult to isolate; this study reveals that cloche encodes a PAS-domain-containing bHLH transcription factor, and a mammalian orthologue can partially rescue cloche mutants, indicating a possible conserved role in mammals.

Suggested Citation

  • Sven Reischauer & Oliver A. Stone & Alethia Villasenor & Neil Chi & Suk-Won Jin & Marcel Martin & Miler T. Lee & Nana Fukuda & Michele Marass & Alec Witty & Ian Fiddes & Taiyi Kuo & Won-Suk Chung & Sh, 2016. "Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification," Nature, Nature, vol. 535(7611), pages 294-298, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7611:d:10.1038_nature18614
    DOI: 10.1038/nature18614
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    Cited by:

    1. Jacob T. Gafranek & Enrico D’Aniello & Padmapriyadarshini Ravisankar & Kairavee Thakkar & Ronald J. Vagnozzi & Hee-Woong Lim & Nathan Salomonis & Joshua S. Waxman, 2023. "Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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