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Interactions between the microbiota and pathogenic bacteria in the gut

Author

Listed:
  • Andreas J. Bäumler

    (University of California, Davis, School of Medicine)

  • Vanessa Sperandio

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.

Suggested Citation

  • Andreas J. Bäumler & Vanessa Sperandio, 2016. "Interactions between the microbiota and pathogenic bacteria in the gut," Nature, Nature, vol. 535(7610), pages 85-93, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18849
    DOI: 10.1038/nature18849
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    Cited by:

    1. Chul Ho Park & Jae Bok Han & Sang Ik Park, 2019. "Dual infection with Entamoeba invadens and Aeromonas hydrophila in a captive anaconda (Eunectes murinus) leading to necrotising gastroenteritis and hepatocyte death," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 64(3), pages 144-148.
    2. Curtis Cottam & Rhys T. White & Lauren C. Beck & Christopher J. Stewart & Scott A. Beatson & Elisabeth C. Lowe & Rhys Grinter & James P. R. Connolly, 2024. "Metabolism of l-arabinose converges with virulence regulation to promote enteric pathogen fitness," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Yohannes Seyoum & Valérie Greffeuille & Dorgeles Kouakou Dje Kouadio & Khov Kuong & Williams Turpin & Rachida M’Rabt & Vincent Chochois & Sonia Fortin & Marlène Perignon & Marion Fiorentino & Jacques , 2024. "Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Colette Mair & Sema Nickbakhsh & Richard Reeve & Jim McMenamin & Arlene Reynolds & Rory N Gunson & Pablo R Murcia & Louise Matthews, 2019. "Estimation of temporal covariances in pathogen dynamics using Bayesian multivariate autoregressive models," PLOS Computational Biology, Public Library of Science, vol. 15(12), pages 1-21, December.
    5. Giuliano Bonanomi & Mohamed Idbella & Ahmed M. Abd-ElGawad, 2021. "Microbiota Management for Effective Disease Suppression: A Systematic Comparison between Soil and Mammals Gut," Sustainability, MDPI, vol. 13(14), pages 1-16, July.
    6. Anna S. Weiss & Lisa S. Niedermeier & Alexandra von Strempel & Anna G. Burrichter & Diana Ring & Chen Meng & Karin Kleigrewe & Chiara Lincetto & Johannes Hübner & Bärbel Stecher, 2023. "Nutritional and host environments determine community ecology and keystone species in a synthetic gut bacterial community," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Chrats Melkonian & Francisco Zorrilla & Inge Kjærbølling & Sonja Blasche & Daniel Machado & Mette Junge & Kim Ib Sørensen & Lene Tranberg Andersen & Kiran R. Patil & Ahmad A. Zeidan, 2023. "Microbial interactions shape cheese flavour formation," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    8. Jacek Piatek & Hanna Krauss & Arleta Ciechelska-Rybarczyk & Malgorzata Bernatek & Paulina Wojtyla-Buciora & Henning Sommermeyer, 2020. "In-Vitro Growth Inhibition of Bacterial Pathogens by Probiotics and a Synbiotic: Product Composition Matters," IJERPH, MDPI, vol. 17(9), pages 1-10, May.
    9. Shengbo Wu & Jie Feng & Chunjiang Liu & Hao Wu & Zekai Qiu & Jianjun Ge & Shuyang Sun & Xia Hong & Yukun Li & Xiaona Wang & Aidong Yang & Fei Guo & Jianjun Qiao, 2022. "Machine learning aided construction of the quorum sensing communication network for human gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. Carsten Eriksen & Janne Marie Moll & Pernille Neve Myers & Ana Rosa Almeida Pinto & Niels Banhos Danneskiold-Samsøe & Rasmus Ibsen Dehli & Lisbeth Buus Rosholm & Marlene Danner Dalgaard & John Penders, 2023. "IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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