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Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Author

Listed:
  • Caleb D. Marceau

    (Stanford University)

  • Andreas S. Puschnik

    (Stanford University)

  • Karim Majzoub

    (Stanford University)

  • Yaw Shin Ooi

    (Stanford University)

  • Susan M. Brewer

    (Stanford University)

  • Gabriele Fuchs

    (Stanford University)

  • Kavya Swaminathan

    (Stanford University)

  • Miguel A. Mata

    (Stanford University)

  • Joshua E. Elias

    (Stanford University)

  • Peter Sarnow

    (Stanford University)

  • Jan E. Carette

    (Stanford University)

Abstract

A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

Suggested Citation

  • Caleb D. Marceau & Andreas S. Puschnik & Karim Majzoub & Yaw Shin Ooi & Susan M. Brewer & Gabriele Fuchs & Kavya Swaminathan & Miguel A. Mata & Joshua E. Elias & Peter Sarnow & Jan E. Carette, 2016. "Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens," Nature, Nature, vol. 535(7610), pages 159-163, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18631
    DOI: 10.1038/nature18631
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    Cited by:

    1. Joseph D. Trimarco & Sarah L. Nelson & Ryan R. Chaparian & Alexandra I. Wells & Nathan B. Murray & Parastoo Azadi & Carolyn B. Coyne & Nicholas S. Heaton, 2022. "Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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