IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v535y2016i7610d10.1038_nature18629.html
   My bibliography  Save this article

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Author

Listed:
  • Xing Liu

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Zhibin Zhang

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Jianbin Ruan

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Youdong Pan

    (Brigham and Women’s Hospital)

  • Venkat Giri Magupalli

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Hao Wu

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Judy Lieberman

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

Abstract

Caspase-mediated cleavage of gasdermin D, previously shown to mediate pyroptosis, acts by inducing oligomerization and pore formation in cell membranes.

Suggested Citation

  • Xing Liu & Zhibin Zhang & Jianbin Ruan & Youdong Pan & Venkat Giri Magupalli & Hao Wu & Judy Lieberman, 2016. "Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores," Nature, Nature, vol. 535(7610), pages 153-158, July.
  • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18629
    DOI: 10.1038/nature18629
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature18629
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature18629?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Keyla S. G. de Sá & Luana A. Amaral & Tamara S. Rodrigues & Adriene Y. Ishimoto & Warrison A. C. Andrade & Leticia Almeida & Felipe Freitas-Castro & Sabrina S. Batah & Sergio C. Oliveira & Mônica T. P, 2023. "Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Jakob Hartmann & Thomas Bajaj & Joy Otten & Claudia Klengel & Tim Ebert & Anne-Kathrin Gellner & Ellen Junglas & Kathrin Hafner & Elmira A. Anderzhanova & Fiona Tang & Galen Missig & Lindsay Rexrode &, 2024. "SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Samuel Speaks & Matthew I. McFadden & Ashley Zani & Abigail Solstad & Steve Leumi & Jack E. Roettger & Adam D. Kenney & Hannah Bone & Lizhi Zhang & Parker J. Denz & Adrian C. Eddy & Amal O. Amer & Ric, 2024. "Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Zhu, Ligang & Li, Xiang & Xu, Fei & Yin, Zhiyong & Jin, Jun & Liu, Zhilong & Qi, Hong & Shuai, Jianwei, 2022. "Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis," Chaos, Solitons & Fractals, Elsevier, vol. 155(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18629. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.