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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Author

Listed:
  • Xing Liu

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Zhibin Zhang

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Jianbin Ruan

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Youdong Pan

    (Brigham and Women’s Hospital)

  • Venkat Giri Magupalli

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Hao Wu

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

  • Judy Lieberman

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital
    Harvard Medical School)

Abstract

Caspase-mediated cleavage of gasdermin D, previously shown to mediate pyroptosis, acts by inducing oligomerization and pore formation in cell membranes.

Suggested Citation

  • Xing Liu & Zhibin Zhang & Jianbin Ruan & Youdong Pan & Venkat Giri Magupalli & Hao Wu & Judy Lieberman, 2016. "Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores," Nature, Nature, vol. 535(7610), pages 153-158, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18629
    DOI: 10.1038/nature18629
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    Cited by:

    1. Keyla S. G. de Sá & Luana A. Amaral & Tamara S. Rodrigues & Adriene Y. Ishimoto & Warrison A. C. Andrade & Leticia Almeida & Felipe Freitas-Castro & Sabrina S. Batah & Sergio C. Oliveira & Mônica T. P, 2023. "Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Jakob Hartmann & Thomas Bajaj & Joy Otten & Claudia Klengel & Tim Ebert & Anne-Kathrin Gellner & Ellen Junglas & Kathrin Hafner & Elmira A. Anderzhanova & Fiona Tang & Galen Missig & Lindsay Rexrode &, 2024. "SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Zhu, Ligang & Li, Xiang & Xu, Fei & Yin, Zhiyong & Jin, Jun & Liu, Zhilong & Qi, Hong & Shuai, Jianwei, 2022. "Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis," Chaos, Solitons & Fractals, Elsevier, vol. 155(C).
    4. Samuel Speaks & Matthew I. McFadden & Ashley Zani & Abigail Solstad & Steve Leumi & Jack E. Roettger & Adam D. Kenney & Hannah Bone & Lizhi Zhang & Parker J. Denz & Adrian C. Eddy & Amal O. Amer & Ric, 2024. "Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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