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A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

Author

Listed:
  • Rong Zhang

    (Washington University School of Medicine)

  • Jonathan J. Miner

    (Washington University School of Medicine)

  • Matthew J. Gorman

    (Washington University School of Medicine)

  • Keiko Rausch

    (Perelman School of Medicine, University of Pennsylvania)

  • Holly Ramage

    (Perelman School of Medicine, University of Pennsylvania)

  • James P. White

    (Washington University School of Medicine)

  • Adam Zuiani

    (Washington University School of Medicine)

  • Ping Zhang

    (Washington University School of Medicine
    Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University)

  • Estefania Fernandez

    (Washington University School of Medicine)

  • Qiang Zhang

    (Washington University School of Medicine)

  • Kimberly A. Dowd

    (Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Theodore C. Pierson

    (Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Sara Cherry

    (Perelman School of Medicine, University of Pennsylvania)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine)

Abstract

Components of the endoplasmic-reticulum-associated signal peptidase complex is required for infection by numerous flaviviruses, including West Nile, dengue and Zika viruses, but is not required for infection by other types of virus or for host protein synthesis.

Suggested Citation

  • Rong Zhang & Jonathan J. Miner & Matthew J. Gorman & Keiko Rausch & Holly Ramage & James P. White & Adam Zuiani & Ping Zhang & Estefania Fernandez & Qiang Zhang & Kimberly A. Dowd & Theodore C. Pierso, 2016. "A CRISPR screen defines a signal peptide processing pathway required by flaviviruses," Nature, Nature, vol. 535(7610), pages 164-168, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18625
    DOI: 10.1038/nature18625
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