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A core viral protein binds host nucleosomes to sequester immune danger signals

Author

Listed:
  • Daphne C. Avgousti

    (University of Pennsylvania Perelman School of Medicine
    Children’s Hospital of Philadelphia)

  • Christin Herrmann

    (Children’s Hospital of Philadelphia
    Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine)

  • Katarzyna Kulej

    (University of Pennsylvania Perelman School of Medicine
    Children’s Hospital of Philadelphia)

  • Neha J. Pancholi

    (Children’s Hospital of Philadelphia
    Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine)

  • Nikolina Sekulic

    (University of Pennsylvania Perelman School of Medicine
    Epigenetics Program, University of Pennsylvania Perelman School of Medicine
    †Present address: Biotechnology Centre of Oslo and Department of Chemistry, University of Oslo, Oslo 0316, Norway.)

  • Joana Petrescu

    (Children’s Hospital of Philadelphia
    Villanova University)

  • Rosalynn C. Molden

    (Epigenetics Program, University of Pennsylvania Perelman School of Medicine)

  • Daniel Blumenthal

    (Children’s Hospital of Philadelphia)

  • Andrew J. Paris

    (Allergy, and Critical Care Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine)

  • Emigdio D. Reyes

    (University of Pennsylvania Perelman School of Medicine
    Children’s Hospital of Philadelphia)

  • Philomena Ostapchuk

    (School of Medicine, Stony Brook University)

  • Patrick Hearing

    (School of Medicine, Stony Brook University)

  • Steven H. Seeholzer

    (Protein and Proteomics Core, Children’s Hospital of Philadelphia)

  • G. Scott Worthen

    (Children’s Hospital of Philadelphia, Philadelphia, University of Pennsylvania Perelman School of Medicine)

  • Ben E. Black

    (University of Pennsylvania Perelman School of Medicine
    Epigenetics Program, University of Pennsylvania Perelman School of Medicine)

  • Benjamin A. Garcia

    (University of Pennsylvania Perelman School of Medicine
    Epigenetics Program, University of Pennsylvania Perelman School of Medicine)

  • Matthew D. Weitzman

    (University of Pennsylvania Perelman School of Medicine
    Children’s Hospital of Philadelphia)

Abstract

Here, a small core protein of human adenoviruses is shown to associate with histones, sequestering proteins on host chromatin and preventing inflammatory proteins from being released and triggering inflammation.

Suggested Citation

  • Daphne C. Avgousti & Christin Herrmann & Katarzyna Kulej & Neha J. Pancholi & Nikolina Sekulic & Joana Petrescu & Rosalynn C. Molden & Daniel Blumenthal & Andrew J. Paris & Emigdio D. Reyes & Philomen, 2016. "A core viral protein binds host nucleosomes to sequester immune danger signals," Nature, Nature, vol. 535(7610), pages 173-177, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18317
    DOI: 10.1038/nature18317
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