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The nature of mutations induced by replication–transcription collisions

Author

Listed:
  • T. Sabari Sankar

    (University of Wisconsin-Madison
    Baylor College of Medicine)

  • Brigitta D. Wastuwidyaningtyas

    (Baylor College of Medicine)

  • Yuexin Dong

    (University of Wisconsin-Madison)

  • Sarah A. Lewis

    (Baylor College of Medicine)

  • Jue D. Wang

    (University of Wisconsin-Madison
    Baylor College of Medicine)

Abstract

When transcription and replication machineries collide on DNA, they can cause mutations to occur in the area near the collision; these mutations are now shown to include two types—duplications/deletions within the transcription unit and base substitutions in the cis-regulatory element of gene expression.

Suggested Citation

  • T. Sabari Sankar & Brigitta D. Wastuwidyaningtyas & Yuexin Dong & Sarah A. Lewis & Jue D. Wang, 2016. "The nature of mutations induced by replication–transcription collisions," Nature, Nature, vol. 535(7610), pages 178-181, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18316
    DOI: 10.1038/nature18316
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    Cited by:

    1. Haoxuan Liu & Jianzhi Zhang, 2022. "Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    2. Houra Merrikh & Christopher Merrikh, 2022. "Reply to: Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes," Nature Communications, Nature, vol. 13(1), pages 1-5, December.

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