IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v535y2016i7610d10.1038_nature18010.html
   My bibliography  Save this article

Design of a hyperstable 60-subunit protein icosahedron

Author

Listed:
  • Yang Hsia

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Biological Physics, Structure and Design, University of Washington)

  • Jacob B. Bale

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington)

  • Shane Gonen

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Biological Physics, Structure and Design, University of Washington
    Janelia Research Campus, Howard Hughes Medical Institute)

  • Dan Shi

    (Janelia Research Campus, Howard Hughes Medical Institute)

  • William Sheffler

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Kimberly K. Fong

    (University of Washington)

  • Una Nattermann

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Biological Physics, Structure and Design, University of Washington)

  • Chunfu Xu

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Po-Ssu Huang

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Rashmi Ravichandran

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Sue Yi

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Trisha N. Davis

    (University of Washington)

  • Tamir Gonen

    (Janelia Research Campus, Howard Hughes Medical Institute)

  • Neil P. King

    (University of Washington
    Institute for Protein Design, University of Washington)

  • David Baker

    (University of Washington
    Institute for Protein Design, University of Washington
    Howard Hughes Medical Institute, University of Washington)

Abstract

The computational design of an extremely stable icosahedral self-assembling protein nanocage is presented; the icosahedron should be useful for applications ranging from calibrating fluorescence microscopy to drug delivery.

Suggested Citation

  • Yang Hsia & Jacob B. Bale & Shane Gonen & Dan Shi & William Sheffler & Kimberly K. Fong & Una Nattermann & Chunfu Xu & Po-Ssu Huang & Rashmi Ravichandran & Sue Yi & Trisha N. Davis & Tamir Gonen & Nei, 2016. "Design of a hyperstable 60-subunit protein icosahedron," Nature, Nature, vol. 535(7610), pages 136-139, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18010
    DOI: 10.1038/nature18010
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature18010
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature18010?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mao Hori & Angela Steinauer & Stephan Tetter & Jamiro Hälg & Eva-Maria Manz & Donald Hilvert, 2024. "Stimulus-responsive assembly of nonviral nucleocapsids," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Yi-Nan Zhang & Jennifer Paynter & Aleksandar Antanasijevic & Joel D. Allen & Mor Eldad & Yi-Zong Lee & Jeffrey Copps & Maddy L. Newby & Linling He & Deborah Chavez & Pat Frost & Anna Goodroe & John Du, 2023. "Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates," Nature Communications, Nature, vol. 14(1), pages 1-29, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18010. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.