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Design of a hyperstable 60-subunit protein icosahedron

Author

Listed:
  • Yang Hsia

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Biological Physics, Structure and Design, University of Washington)

  • Jacob B. Bale

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington)

  • Shane Gonen

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Biological Physics, Structure and Design, University of Washington
    Janelia Research Campus, Howard Hughes Medical Institute)

  • Dan Shi

    (Janelia Research Campus, Howard Hughes Medical Institute)

  • William Sheffler

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Kimberly K. Fong

    (University of Washington)

  • Una Nattermann

    (University of Washington
    Institute for Protein Design, University of Washington
    Graduate Program in Biological Physics, Structure and Design, University of Washington)

  • Chunfu Xu

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Po-Ssu Huang

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Rashmi Ravichandran

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Sue Yi

    (University of Washington
    Institute for Protein Design, University of Washington)

  • Trisha N. Davis

    (University of Washington)

  • Tamir Gonen

    (Janelia Research Campus, Howard Hughes Medical Institute)

  • Neil P. King

    (University of Washington
    Institute for Protein Design, University of Washington)

  • David Baker

    (University of Washington
    Institute for Protein Design, University of Washington
    Howard Hughes Medical Institute, University of Washington)

Abstract

The computational design of an extremely stable icosahedral self-assembling protein nanocage is presented; the icosahedron should be useful for applications ranging from calibrating fluorescence microscopy to drug delivery.

Suggested Citation

  • Yang Hsia & Jacob B. Bale & Shane Gonen & Dan Shi & William Sheffler & Kimberly K. Fong & Una Nattermann & Chunfu Xu & Po-Ssu Huang & Rashmi Ravichandran & Sue Yi & Trisha N. Davis & Tamir Gonen & Nei, 2016. "Design of a hyperstable 60-subunit protein icosahedron," Nature, Nature, vol. 535(7610), pages 136-139, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18010
    DOI: 10.1038/nature18010
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    Cited by:

    1. Yi-Nan Zhang & Jennifer Paynter & Aleksandar Antanasijevic & Joel D. Allen & Mor Eldad & Yi-Zong Lee & Jeffrey Copps & Maddy L. Newby & Linling He & Deborah Chavez & Pat Frost & Anna Goodroe & John Du, 2023. "Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates," Nature Communications, Nature, vol. 14(1), pages 1-29, December.
    2. Mao Hori & Angela Steinauer & Stephan Tetter & Jamiro Hälg & Eva-Maria Manz & Donald Hilvert, 2024. "Stimulus-responsive assembly of nonviral nucleocapsids," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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