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H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

Author

Listed:
  • Giulia Saredi

    (Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Hongda Huang

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Colin M. Hammond

    (Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Constance Alabert

    (Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Simon Bekker-Jensen

    (The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen)

  • Ignasi Forne

    (Biomedical Center and Center for Integrated Protein Science Munich, Ludwig-Maximilians University)

  • Nazaret Reverón-Gómez

    (Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Benjamin M. Foster

    (MRC Clinical Sciences Centre (CSC) and Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Lucie Mlejnkova

    (Institute of Molecular Cancer Research, University of Zurich)

  • Till Bartke

    (MRC Clinical Sciences Centre (CSC) and Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Petr Cejka

    (Institute of Molecular Cancer Research, University of Zurich)

  • Niels Mailand

    (The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen)

  • Axel Imhof

    (Biomedical Center and Center for Integrated Protein Science Munich, Ludwig-Maximilians University)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Anja Groth

    (Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, Faculty of Health and Medical Sciences, University of Copenhagen)

Abstract

We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature of post-replicative chromatin, which is specifically recognized by the homologous recombination complex TONSL–MMS22L.

Suggested Citation

  • Giulia Saredi & Hongda Huang & Colin M. Hammond & Constance Alabert & Simon Bekker-Jensen & Ignasi Forne & Nazaret Reverón-Gómez & Benjamin M. Foster & Lucie Mlejnkova & Till Bartke & Petr Cejka & Nie, 2016. "H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex," Nature, Nature, vol. 534(7609), pages 714-718, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7609:d:10.1038_nature18312
    DOI: 10.1038/nature18312
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    Cited by:

    1. Junliang Chen & Mingjie Wu & Yulan Yang & Chunyan Ruan & Yi Luo & Lizhi Song & Ting Wu & Jun Huang & Bing Yang & Ting Liu, 2024. "TFIP11 promotes replication fork reversal to preserve genome stability," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Susan Kilgas & Aleem Syed & Patrick Toolan-Kerr & Michelle L. Swift & Shrabasti Roychoudhury & Aniruddha Sarkar & Sarah Wilkins & Mikayla Quigley & Anna R. Poetsch & Maria Victoria Botuyan & Gaofeng C, 2024. "NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Takuya Tsujino & Tomoaki Takai & Kunihiko Hinohara & Fu Gui & Takeshi Tsutsumi & Xiao Bai & Chenkui Miao & Chao Feng & Bin Gui & Zsofia Sztupinszki & Antoine Simoneau & Ning Xie & Ladan Fazli & Xuesen, 2023. "CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. Marieke R. Wensveen & Aditya A. Dixit & Robin Schendel & Apfrida Kendek & Jan-Paul Lambooij & Marcel Tijsterman & Serafin U. Colmenares & Aniek Janssen, 2024. "Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Zhen Wang & Claudia M. Castillo-González & Changjiang Zhao & Chun-Yip Tong & Changhao Li & Songxiao Zhong & Zhiyang Liu & Kaili Xie & Jiaying Zhu & Zhongshou Wu & Xu Peng & Yannick Jacob & Scott D. Mi, 2023. "H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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