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Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

Author

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  • Umeharu Ohto

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo)

  • Hanako Ishida

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo)

  • Elena Krayukhina

    (Graduate School of Engineering, Osaka University)

  • Susumu Uchiyama

    (Graduate School of Engineering, Osaka University
    Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences)

  • Naokazu Inoue

    (Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University)

  • Toshiyuki Shimizu

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo)

Abstract

The structure of the IZUMO1–JUNO complex, crucial for sperm–oocyte interaction during fertilization, is reported, providing a first step towards understanding the mechanics of the interaction.

Suggested Citation

  • Umeharu Ohto & Hanako Ishida & Elena Krayukhina & Susumu Uchiyama & Naokazu Inoue & Toshiyuki Shimizu, 2016. "Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization," Nature, Nature, vol. 534(7608), pages 566-569, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7608:d:10.1038_nature18596
    DOI: 10.1038/nature18596
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