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A complement–microglial axis drives synapse loss during virus-induced memory impairment

Author

Listed:
  • Michael J. Vasek

    (Washington University School of Medicine)

  • Charise Garber

    (Washington University School of Medicine)

  • Denise Dorsey

    (Washington University School of Medicine)

  • Douglas M. Durrant

    (Washington University School of Medicine
    California State Polytechnic University)

  • Bryan Bollman

    (Washington University School of Medicine)

  • Allison Soung

    (Washington University School of Medicine)

  • Jinsheng Yu

    (Washington University School of Medicine)

  • Carlos Perez-Torres

    (Washington University School of Medicine)

  • Arnaud Frouin

    (F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School)

  • Daniel K. Wilton

    (F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School)

  • Kristen Funk

    (Washington University School of Medicine)

  • Bette K. DeMasters

    (University of Colorado School of Medicine)

  • Xiaoping Jiang

    (Washington University School of Medicine)

  • James R. Bowen

    (Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine)

  • Steven Mennerick

    (Washington University School of Medicine)

  • John K. Robinson

    (Stony Brook University)

  • Joel R. Garbow

    (Washington University School of Medicine)

  • Kenneth L. Tyler

    (University of Colorado School of Medicine)

  • Mehul S. Suthar

    (Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine)

  • Robert E. Schmidt

    (Washington University School of Medicine)

  • Beth Stevens

    (F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School)

  • Robyn S. Klein

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

Abstract

People infected with West Nile virus often experience cognitive side effects including memory loss through unknown mechanisms; mice and humans infected with the virus experience a loss in hippocampal presynaptic terminals, which can be reversed by disrupting complement or microglia in mice.

Suggested Citation

  • Michael J. Vasek & Charise Garber & Denise Dorsey & Douglas M. Durrant & Bryan Bollman & Allison Soung & Jinsheng Yu & Carlos Perez-Torres & Arnaud Frouin & Daniel K. Wilton & Kristen Funk & Bette K. , 2016. "A complement–microglial axis drives synapse loss during virus-induced memory impairment," Nature, Nature, vol. 534(7608), pages 538-543, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7608:d:10.1038_nature18283
    DOI: 10.1038/nature18283
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    Cited by:

    1. Noriko Itoh & Yuichiro Itoh & Cassandra E. Meyer & Timothy Takazo Suen & Diego Cortez-Delgado & Michelle Rivera Lomeli & Sophia Wendin & Sri Sanjana Somepalli & Lisa C. Golden & Allan MacKenzie-Graham, 2023. "Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Shih-Ching Lin & Fang R. Zhao & Hana Janova & Adrian Gervais & Summer Rucknagel & Kristy O. Murray & Jean-Laurent Casanova & Michael S. Diamond, 2023. "Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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