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AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Author

Listed:
  • Hi-Jai R. Shin

    (Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University)

  • Hyunkyung Kim

    (Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University)

  • Sungryong Oh

    (Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University)

  • Jun-Gi Lee

    (Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University)

  • Minjung Kee

    (Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University)

  • Hyun-Jeong Ko

    (Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University)

  • Mi-Na Kweon

    (Mucosal Immunology Laboratory, University of Ulsan College of Medicine, Asan Medical Center)

  • Kyoung-Jae Won

    (The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania)

  • Sung Hee Baek

    (Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University)

Abstract

An investigation into the nuclear events involved in autophagy regulation identifies the histone arginine methyltransferase CARM1 as a transcriptional co-activator of transcription factor TFEB; CARM1 levels are decreased by the SKP2-containing E3 ubiquitin ligase and increased during autophagy induction after nutrient starvation.

Suggested Citation

  • Hi-Jai R. Shin & Hyunkyung Kim & Sungryong Oh & Jun-Gi Lee & Minjung Kee & Hyun-Jeong Ko & Mi-Na Kweon & Kyoung-Jae Won & Sung Hee Baek, 2016. "AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy," Nature, Nature, vol. 534(7608), pages 553-557, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7608:d:10.1038_nature18014
    DOI: 10.1038/nature18014
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    Cited by:

    1. Ji-Man Park & Da-Hye Lee & Do-Hyung Kim, 2023. "Redefining the role of AMPK in autophagy and the energy stress response," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Fei He & Qi Yu & Min Wang & Rongsha Wang & Xuanyunjing Gong & Feng Ge & Xilan Yu & Shanshan Li, 2022. "SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. WeiChao Hao & MeiJuan Dian & Ying Zhou & QiuLing Zhong & WenQian Pang & ZiJian Li & YaYan Zhao & JiaCheng Ma & XiaoLin Lin & RenRu Luo & YongLong Li & JunShuang Jia & HongFen Shen & ShiHao Huang & Gua, 2022. "Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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