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Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Author

Listed:
  • Louise A. Hyslop

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life)

  • Paul Blakeley

    (The Francis Crick Institute, Human Embryo and Stem Cell Laboratory)

  • Lyndsey Craven

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School)

  • Jessica Richardson

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life)

  • Norah M. E. Fogarty

    (The Francis Crick Institute, Human Embryo and Stem Cell Laboratory)

  • Elpida Fragouli

    (Reprogenetics UK, Institute of Reproductive Sciences)

  • Mahdi Lamb

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life)

  • Sissy E. Wamaitha

    (The Francis Crick Institute, Human Embryo and Stem Cell Laboratory)

  • Nilendran Prathalingam

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life)

  • Qi Zhang

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    †Present addresses: Department of Cell Biology, Academy of Military Medical Sciences, No. 27th Taiping Road, HaiDian, Beijing 100850, China (Q.Z.); Gateshead Fertility Unit, Gateshead Health NHS Trust, Queen Elizabeth Hospital, Sheriff Hill, Gateshead NE9 6SX, UK (L.I.); St Mary’s Hospital, Department of Reproductive Medicine, Old Saint Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK (D.K.).)

  • Hannah O’Keefe

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life)

  • Yuko Takeda

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life)

  • Lucia Arizzi

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life)

  • Samer Alfarawati

    (Reprogenetics UK, Institute of Reproductive Sciences)

  • Helen A. Tuppen

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School)

  • Laura Irving

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    †Present addresses: Department of Cell Biology, Academy of Military Medical Sciences, No. 27th Taiping Road, HaiDian, Beijing 100850, China (Q.Z.); Gateshead Fertility Unit, Gateshead Health NHS Trust, Queen Elizabeth Hospital, Sheriff Hill, Gateshead NE9 6SX, UK (L.I.); St Mary’s Hospital, Department of Reproductive Medicine, Old Saint Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK (D.K.).)

  • Dimitrios Kalleas

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    †Present addresses: Department of Cell Biology, Academy of Military Medical Sciences, No. 27th Taiping Road, HaiDian, Beijing 100850, China (Q.Z.); Gateshead Fertility Unit, Gateshead Health NHS Trust, Queen Elizabeth Hospital, Sheriff Hill, Gateshead NE9 6SX, UK (L.I.); St Mary’s Hospital, Department of Reproductive Medicine, Old Saint Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK (D.K.).)

  • Meenakshi Choudhary

    (Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life)

  • Dagan Wells

    (University of Oxford)

  • Alison P. Murdoch

    (Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life)

  • Douglass M. Turnbull

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School)

  • Kathy K. Niakan

    (The Francis Crick Institute, Human Embryo and Stem Cell Laboratory)

  • Mary Herbert

    (Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life
    Newcastle Fertility Centre, Biomedicine West Wing, Centre for Life)

Abstract

Preclinical evaluation and optimization of mitochondrial replacement therapy reveals that a modified form of pronuclear transfer is likely to give rise to normal pregnancies with a reduced risk of mitochondrial DNA disease, but may need further modification to eradicate the disease in all cases.

Suggested Citation

  • Louise A. Hyslop & Paul Blakeley & Lyndsey Craven & Jessica Richardson & Norah M. E. Fogarty & Elpida Fragouli & Mahdi Lamb & Sissy E. Wamaitha & Nilendran Prathalingam & Qi Zhang & Hannah O’Keefe & Y, 2016. "Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease," Nature, Nature, vol. 534(7607), pages 383-386, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7607:d:10.1038_nature18303
    DOI: 10.1038/nature18303
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