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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Author

Listed:
  • Lena M. Kranz

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University)

  • Mustafa Diken

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Heinrich Haas

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Sebastian Kreiter

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Carmen Loquai

    (University Medical Center of the Johannes Gutenberg University)

  • Kerstin C. Reuter

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Martin Meng

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Daniel Fritz

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Fulvia Vascotto

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH)

  • Hossam Hefesha

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Christian Grunwitz

    (Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University
    Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Mathias Vormehr

    (Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University
    Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Yves Hüsemann

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Abderraouf Selmi

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University)

  • Andreas N. Kuhn

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Janina Buck

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Evelyna Derhovanessian

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Richard Rae

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH)

  • Sebastian Attig

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University)

  • Jan Diekmann

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Robert A. Jabulowsky

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Sandra Heesch

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Jessica Hassel

    (Heidelberg University Hospital)

  • Peter Langguth

    (Institute of Pharmacy and Biochemistry, Johannes Gutenberg University)

  • Stephan Grabbe

    (University Medical Center of the Johannes Gutenberg University)

  • Christoph Huber

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Özlem Türeci

    (Cluster for Individualized Immune Intervention)

  • Ugur Sahin

    (TRON–Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
    Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University
    Biopharmaceutical New Technologies (BioNTech) Corporation)

Abstract

The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.

Suggested Citation

  • Lena M. Kranz & Mustafa Diken & Heinrich Haas & Sebastian Kreiter & Carmen Loquai & Kerstin C. Reuter & Martin Meng & Daniel Fritz & Fulvia Vascotto & Hossam Hefesha & Christian Grunwitz & Mathias Vor, 2016. "Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy," Nature, Nature, vol. 534(7607), pages 396-401, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7607:d:10.1038_nature18300
    DOI: 10.1038/nature18300
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    Cited by:

    1. Xuan Wang & Yingqi Liu & Chencheng Xue & Yan Hu & Yuanyuan Zhao & Kaiyong Cai & Menghuan Li & Zhong Luo, 2022. "A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Wanbo Tai & Kai Yang & Yubin Liu & Ruofan Li & Shengyong Feng & Benjie Chai & Xinyu Zhuang & Shaolong Qi & Huicheng Shi & Zhida Liu & Jiaqi Lei & Enhao Ma & Weixiao Wang & Chongyu Tian & Ting Le & Jin, 2023. "A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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