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Co-repressor CBFA2T2 regulates pluripotency and germline development

Author

Listed:
  • Shengjiang Tu

    (Howard Hughes Medical Institute, New York University School of Medicine
    New York University School of Medicine)

  • Varun Narendra

    (Howard Hughes Medical Institute, New York University School of Medicine
    New York University School of Medicine)

  • Masashi Yamaji

    (Howard Hughes Medical Institute, Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Simon E. Vidal

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • Luis Alejandro Rojas

    (Howard Hughes Medical Institute, New York University School of Medicine
    New York University School of Medicine)

  • Xiaoshi Wang

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Sang Yong Kim

    (Rodent Genetic Engineering Core, NYU School of Medicine)

  • Benjamin A. Garcia

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Thomas Tuschl

    (Howard Hughes Medical Institute, Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Matthias Stadtfeld

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • Danny Reinberg

    (Howard Hughes Medical Institute, New York University School of Medicine
    New York University School of Medicine)

Abstract

A co-repressor protein, CBFA2T2, oligomerizes to stabilize its binding partner PRDM14 and the pluripotency factor OCT4 on chromatin, thus facilitating the transcriptional landscape underpinning the germline and pluripotent fate.

Suggested Citation

  • Shengjiang Tu & Varun Narendra & Masashi Yamaji & Simon E. Vidal & Luis Alejandro Rojas & Xiaoshi Wang & Sang Yong Kim & Benjamin A. Garcia & Thomas Tuschl & Matthias Stadtfeld & Danny Reinberg, 2016. "Co-repressor CBFA2T2 regulates pluripotency and germline development," Nature, Nature, vol. 534(7607), pages 387-390, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7607:d:10.1038_nature18004
    DOI: 10.1038/nature18004
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    Cited by:

    1. Zeinab Asgarian & Marcio Guiomar Oliveira & Agata Stryjewska & Ioannis Maragkos & Anna Noren Rubin & Lorenza Magno & Vassilis Pachnis & Mohammadmersad Ghorbani & Scott Wayne Hiebert & Myrto Denaxa & N, 2022. "MTG8 interacts with LHX6 to specify cortical interneuron subtype identity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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