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Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

Author

Listed:
  • Raymond G. Fox

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Nikki K. Lytle

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Dawn V. Jaquish

    (Moores Cancer Center, University of California San Diego School of Medicine
    University of California San Diego School of Medicine)

  • Frederick D. Park

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Takahiro Ito

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Jeevisha Bajaj

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Claire S. Koechlein

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Bryan Zimdahl

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Masato Yano

    (Keio University School of Medicine
    †Present address: Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachidori, Chuo-ku, Niigata 951-8510, Japan.)

  • Janel L. Kopp

    (Sanford Consortium for Regenerative Medicine
    University of California San Diego School of Medicine)

  • Marcie Kritzik

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

  • Jason K. Sicklick

    (Moores Cancer Center, University of California San Diego School of Medicine
    University of California San Diego School of Medicine)

  • Maike Sander

    (Sanford Consortium for Regenerative Medicine
    University of California San Diego School of Medicine)

  • Paul M. Grandgenett

    (Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center)

  • Michael A. Hollingsworth

    (Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center)

  • Shinsuke Shibata

    (Keio University School of Medicine)

  • Donald Pizzo

    (University of California San Diego School of Medicine)

  • Mark A. Valasek

    (University of California San Diego School of Medicine)

  • Roman Sasik

    (Center for Computational Biology and Bioinformatics, University of California San Diego School of Medicine)

  • Miriam Scadeng

    (University of California San Diego School of Medicine)

  • Hideyuki Okano

    (Keio University School of Medicine)

  • Youngsoo Kim

    (Ionis Pharmaceuticals)

  • A. Robert MacLeod

    (Ionis Pharmaceuticals)

  • Andrew M. Lowy

    (Moores Cancer Center, University of California San Diego School of Medicine
    University of California San Diego School of Medicine)

  • Tannishtha Reya

    (University of California San Diego School of Medicine La Jolla
    University of California San Diego School of Medicine La Jolla
    Sanford Consortium for Regenerative Medicine
    Moores Cancer Center, University of California San Diego School of Medicine)

Abstract

The stem cell determinant Musashi (Msi) is a key mediator of pancreatic cancer progression and therapy resistance.

Suggested Citation

  • Raymond G. Fox & Nikki K. Lytle & Dawn V. Jaquish & Frederick D. Park & Takahiro Ito & Jeevisha Bajaj & Claire S. Koechlein & Bryan Zimdahl & Masato Yano & Janel L. Kopp & Marcie Kritzik & Jason K. Si, 2016. "Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma," Nature, Nature, vol. 534(7607), pages 407-411, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7607:d:10.1038_nature17988
    DOI: 10.1038/nature17988
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    Cited by:

    1. L. Paige Ferguson & Jovylyn Gatchalian & Matthew L. McDermott & Mari Nakamura & Kendall Chambers & Nirakar Rajbhandari & Nikki K. Lytle & Sara Brin Rosenthal & Michael Hamilton & Sonia Albini & Martin, 2023. "Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Michelle M. Kameda-Smith & Helen Zhu & En-Ching Luo & Yujin Suk & Agata Xella & Brian Yee & Chirayu Chokshi & Sansi Xing & Frederick Tan & Raymond G. Fox & Ashley A. Adile & David Bakhshinyan & Kevin , 2022. "Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Shigekazu Murakami & Shannon M. White & Alec T. McIntosh & Chan D. K. Nguyen & Chunling Yi, 2023. "Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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