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The Brazilian Zika virus strain causes birth defects in experimental models

Author

Listed:
  • Fernanda R. Cugola

    (University of São Paulo, Stem Cell Laboratory)

  • Isabella R. Fernandes

    (University of São Paulo, Stem Cell Laboratory
    University of California San Diego, School of Medicine, Stem Cell Program)

  • Fabiele B. Russo

    (University of São Paulo, Stem Cell Laboratory
    Tismoo, The Biotech Company)

  • Beatriz C. Freitas

    (University of California San Diego, School of Medicine, Stem Cell Program)

  • João L. M. Dias

    (University of São Paulo, Stem Cell Laboratory)

  • Katia P. Guimarães

    (University of São Paulo, Stem Cell Laboratory)

  • Cecília Benazzato

    (University of São Paulo, Stem Cell Laboratory)

  • Nathalia Almeida

    (University of São Paulo, Stem Cell Laboratory)

  • Graciela C. Pignatari

    (University of São Paulo, Stem Cell Laboratory
    Tismoo, The Biotech Company)

  • Sarah Romero

    (University of California San Diego, School of Medicine, Stem Cell Program)

  • Carolina M. Polonio

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • Isabela Cunha

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • Carla L. Freitas

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • Wesley N. Brandão

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • Cristiano Rossato

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • David G. Andrade

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • Daniele de P. Faria

    (University of São Paulo, USP School of Medicine)

  • Alexandre T. Garcez

    (University of São Paulo, USP School of Medicine)

  • Carlos A. Buchpigel

    (University of São Paulo, USP School of Medicine)

  • Carla T. Braconi

    (University of São Paulo, Institute of Microbiology Sciences, Laboratory of Molecular Evolution and Bioinformatics)

  • Erica Mendes

    (University of São Paulo, Institute of Microbiology Sciences, Laboratory of Molecular Evolution and Bioinformatics)

  • Amadou A. Sall

    (Institute Pasteur in Dakar)

  • Paolo M. de A. Zanotto

    (University of São Paulo, Institute of Microbiology Sciences, Laboratory of Molecular Evolution and Bioinformatics)

  • Jean Pierre S. Peron

    (University of São Paulo, Neuroimmune Interactions Laboratory)

  • Alysson R. Muotri

    (University of California San Diego, School of Medicine, Stem Cell Program)

  • Patricia C. B. Beltrão-Braga

    (University of São Paulo, Stem Cell Laboratory
    University of São Paulo, School of Arts, Sciences and Humanities)

Abstract

Brazilian Zika virus causes birth defects in mice Zika virus infection has been linked to an increase in the number of infants born with microcephaly in Brazil, but direct experimental proof that Zika virus causes birth defects was lacking. Here Alysson Muotri and colleagues show that the Brazilian Zika virus strain can cross the placenta and cause intrauterine growth restriction, including signs of microcephaly, in the SJL strain of mice. They also show that the virus can infect human brain organoids, inducing cell death by apoptosis and disrupting cortical layers.

Suggested Citation

  • Fernanda R. Cugola & Isabella R. Fernandes & Fabiele B. Russo & Beatriz C. Freitas & João L. M. Dias & Katia P. Guimarães & Cecília Benazzato & Nathalia Almeida & Graciela C. Pignatari & Sarah Romero , 2016. "The Brazilian Zika virus strain causes birth defects in experimental models," Nature, Nature, vol. 534(7606), pages 267-271, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature18296
    DOI: 10.1038/nature18296
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    Cited by:

    1. Ahmad Naqib Shuid & Putri Ayu Jayusman & Nazrun Shuid & Juriza Ismail & Norazlin Kamal Nor & Isa Naina Mohamed, 2021. "Association between Viral Infections and Risk of Autistic Disorder: An Overview," IJERPH, MDPI, vol. 18(6), pages 1-17, March.
    2. Pamela E. Capendale & Inés García-Rodríguez & Anoop T. Ambikan & Lance A. Mulder & Josse A. Depla & Eline Freeze & Gerrit Koen & Carlemi Calitz & Vikas Sood & Renata Vieira de Sá & Ujjwal Neogi & Dasj, 2024. "Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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