IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v534y2016i7606d10.1038_nature17963.html
   My bibliography  Save this article

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Author

Listed:
  • Vanessa S. Rodrik-Outmezguine

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center)

  • Masanori Okaniwa

    (University of California San Francisco)

  • Zhan Yao

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center)

  • Chris J. Novotny

    (University of California San Francisco)

  • Claire McWhirter

    (AstraZeneca, Alderley Park)

  • Arpitha Banaji

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center)

  • Helen Won

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Wai Wong

    (Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center)

  • Mike Berger

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Elisa de Stanchina

    (Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center)

  • Derek G. Barratt

    (AstraZeneca, Alderley Park)

  • Sabina Cosulich

    (AstraZeneca, Alderley Park)

  • Teresa Klinowska

    (AstraZeneca, Alderley Park)

  • Neal Rosen

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Kevan M. Shokat

    (University of California San Francisco
    University of California Berkeley)

Abstract

Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance.

Suggested Citation

  • Vanessa S. Rodrik-Outmezguine & Masanori Okaniwa & Zhan Yao & Chris J. Novotny & Claire McWhirter & Arpitha Banaji & Helen Won & Wai Wong & Mike Berger & Elisa de Stanchina & Derek G. Barratt & Sabina, 2016. "Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor," Nature, Nature, vol. 534(7606), pages 272-276, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature17963
    DOI: 10.1038/nature17963
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature17963
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature17963?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sébastien Levesque & Diana Mayorga & Jean-Philippe Fiset & Claudia Goupil & Alexis Duringer & Andréanne Loiselle & Eva Bouchard & Daniel Agudelo & Yannick Doyon, 2022. "Marker-free co-selection for successive rounds of prime editing in human cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Hidenori Kitai & Philip H. Choi & Yu C. Yang & Jacob A. Boyer & Adele Whaley & Priya Pancholi & Claire Thant & Jason Reiter & Kevin Chen & Vladimir Markov & Hirokazu Taniguchi & Rui Yamaguchi & Hiromi, 2024. "Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature17963. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.