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Ribosome-dependent activation of stringent control

Author

Listed:
  • Alan Brown

    (MRC Laboratory of Molecular Biology)

  • Israel S. Fernández

    (MRC Laboratory of Molecular Biology
    †Present address: Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.)

  • Yuliya Gordiyenko

    (MRC Laboratory of Molecular Biology)

  • V. Ramakrishnan

    (MRC Laboratory of Molecular Biology)

Abstract

The structure of a bacterial ribosome–RelA complex reveals that RelA, a protein recruited to the ribosome in the case of scarce amino acids, binds in a different location to translation factors, and that this binding event suppresses auto-inhibition to activate synthesis of the (p)ppGpp secondary messenger, thus initiating stringent control.

Suggested Citation

  • Alan Brown & Israel S. Fernández & Yuliya Gordiyenko & V. Ramakrishnan, 2016. "Ribosome-dependent activation of stringent control," Nature, Nature, vol. 534(7606), pages 277-280, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature17675
    DOI: 10.1038/nature17675
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    Cited by:

    1. Manlu Zhu & Xiongfeng Dai, 2023. "Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Laura Czech & Christopher-Nils Mais & Hanna Kratzat & Pinku Sarmah & Pietro Giammarinaro & Sven-Andreas Freibert & Hanna Folke Esser & Joanna Musial & Otto Berninghausen & Wieland Steinchen & Roland B, 2022. "Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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