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Structure of the thermally stable Zika virus

Author

Listed:
  • Victor A. Kostyuchenko

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

  • Elisa X. Y. Lim

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

  • Shuijun Zhang

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

  • Guntur Fibriansah

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

  • Thiam-Seng Ng

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

  • Justin S. G. Ooi

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

  • Jian Shi

    (Centre for BioImaging Sciences, National University of Singapore
    CryoEM unit, National University of Singapore)

  • Shee-Mei Lok

    (Program in Emerging Infectious Diseases, Duke–National University of Singapore Medical School
    Centre for BioImaging Sciences, National University of Singapore)

Abstract

The 3.7 Å cryo-electron microscopy structure of Zika virus is presented, revealing a typical flavivirus architecture; in contrast to the related flavivirus dengue virus, Zika virus is thermally stable at 40 °C, and this structural stability may be a feature that helps it to survive in semen, saliva and urine.

Suggested Citation

  • Victor A. Kostyuchenko & Elisa X. Y. Lim & Shuijun Zhang & Guntur Fibriansah & Thiam-Seng Ng & Justin S. G. Ooi & Jian Shi & Shee-Mei Lok, 2016. "Structure of the thermally stable Zika virus," Nature, Nature, vol. 533(7603), pages 425-428, May.
  • Handle: RePEc:nat:nature:v:533:y:2016:i:7603:d:10.1038_nature17994
    DOI: 10.1038/nature17994
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