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Molecular mechanism of APC/C activation by mitotic phosphorylation

Author

Listed:
  • Suyang Zhang

    (MRC Laboratory of Molecular Biology)

  • Leifu Chang

    (MRC Laboratory of Molecular Biology)

  • Claudio Alfieri

    (MRC Laboratory of Molecular Biology)

  • Ziguo Zhang

    (MRC Laboratory of Molecular Biology)

  • Jing Yang

    (MRC Laboratory of Molecular Biology)

  • Sarah Maslen

    (MRC Laboratory of Molecular Biology)

  • Mark Skehel

    (MRC Laboratory of Molecular Biology)

  • David Barford

    (MRC Laboratory of Molecular Biology)

Abstract

Phosphorylation of the anaphase-promoting complex (APC/C) allows for its control by the co-activator Cdc20; a mechanism that has relevance to understanding the control of other large multimeric complexes by phosphorylation.

Suggested Citation

  • Suyang Zhang & Leifu Chang & Claudio Alfieri & Ziguo Zhang & Jing Yang & Sarah Maslen & Mark Skehel & David Barford, 2016. "Molecular mechanism of APC/C activation by mitotic phosphorylation," Nature, Nature, vol. 533(7602), pages 260-264, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7602:d:10.1038_nature17973
    DOI: 10.1038/nature17973
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    Cited by:

    1. Anna Höfler & Jun Yu & Jing Yang & Ziguo Zhang & Leifu Chang & Stephen H. McLaughlin & Geoffrey W. Grime & Elspeth F. Garman & Andreas Boland & David Barford, 2024. "Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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