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Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

Author

Listed:
  • Libin Ye

    (University of Toronto, UTM
    University of Toronto)

  • Ned Van Eps

    (University of Toronto)

  • Marco Zimmer

    (University of Toronto
    University of Stuttgart)

  • Oliver P. Ernst

    (University of Toronto
    University of Toronto)

  • R. Scott Prosser

    (University of Toronto, UTM
    University of Toronto)

Abstract

The adenosine A2A receptor, a class A G-protein-coupled receptor, exists as an ensemble of two inactive and two active states in equilibrium and is activated by conformational selection rather than induced fit.

Suggested Citation

  • Libin Ye & Ned Van Eps & Marco Zimmer & Oliver P. Ernst & R. Scott Prosser, 2016. "Activation of the A2A adenosine G-protein-coupled receptor by conformational selection," Nature, Nature, vol. 533(7602), pages 265-268, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7602:d:10.1038_nature17668
    DOI: 10.1038/nature17668
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    Cited by:

    1. Xudong Wang & Chris Neale & Soo-Kyung Kim & William A. Goddard & Libin Ye, 2023. "Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Andrew J. Y. Jones & Thomas H. Harman & Matthew Harris & Oliver E. Lewis & Graham Ladds & Daniel Nietlispach, 2024. "Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Kazem Asadollahi & Sunnia Rajput & Lazarus Andrew Zhang & Ching-Seng Ang & Shuai Nie & Nicholas A. Williamson & Michael D. W. Griffin & Ross A. D. Bathgate & Daniel J. Scott & Thomas R. Weikl & Guy N., 2023. "Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Robert E. Jefferson & Aurélien Oggier & Andreas Füglistaler & Nicolas Camviel & Mahdi Hijazi & Ana Rico Villarreal & Caroline Arber & Patrick Barth, 2023. "Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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