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Extra-helical binding site of a glucagon receptor antagonist

Author

Listed:
  • Ali Jazayeri

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Andrew S. Doré

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Daniel Lamb

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Harini Krishnamurthy

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Stacey M. Southall

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Asma H. Baig

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Andrea Bortolato

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Markus Koglin

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Nathan J. Robertson

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • James C. Errey

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Stephen P. Andrews

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Iryna Teobald

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Alastair J. H. Brown

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Robert M. Cooke

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Malcolm Weir

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Fiona H. Marshall

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

Abstract

The X-ray crystal structure of the transmembrane portion of the human glucagon receptor, a class B G-protein-coupled receptor (GPCR), is solved in the presence of the antagonist MK-0893, with potential implications for the development of therapeutics that target other class B GPCRs.

Suggested Citation

  • Ali Jazayeri & Andrew S. Doré & Daniel Lamb & Harini Krishnamurthy & Stacey M. Southall & Asma H. Baig & Andrea Bortolato & Markus Koglin & Nathan J. Robertson & James C. Errey & Stephen P. Andrews & , 2016. "Extra-helical binding site of a glucagon receptor antagonist," Nature, Nature, vol. 533(7602), pages 274-277, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7602:d:10.1038_nature17414
    DOI: 10.1038/nature17414
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    Cited by:

    1. Xueqian Peng & Linlin Yang & Zixuan Liu & Siyi Lou & Shiliu Mei & Meiling Li & Zhong Chen & Haitao Zhang, 2022. "Structural basis for recognition of antihistamine drug by human histamine receptor," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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