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Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

Author

Listed:
  • Stefan Rentas

    (Stem Cell and Cancer Research Institute, McMaster University)

  • Nicholas T. Holzapfel

    (Stem Cell and Cancer Research Institute, McMaster University)

  • Muluken S. Belew

    (Stem Cell and Cancer Research Institute, McMaster University)

  • Gabriel A. Pratt

    (Institute for Genomic Medicine, University of California, San Diego
    Bioinformatics Graduate Program, University of California, San Diego)

  • Veronique Voisin

    (The Donnelly Centre, University of Toronto)

  • Brian T. Wilhelm

    (Institute for Research in Immunology and Cancer, University of Montreal)

  • Gary D. Bader

    (The Donnelly Centre, University of Toronto)

  • Gene W. Yeo

    (Institute for Genomic Medicine, University of California, San Diego
    Bioinformatics Graduate Program, University of California, San Diego
    National University of Singapore and Molecular Engineering Laboratory)

  • Kristin J. Hope

    (Stem Cell and Cancer Research Institute, McMaster University)

Abstract

The RNA-binding protein Musashi-2 increases the self-renewing abilities of human haematopoietic stem cells, which have the potential to be used for regenerative therapies.

Suggested Citation

  • Stefan Rentas & Nicholas T. Holzapfel & Muluken S. Belew & Gabriel A. Pratt & Veronique Voisin & Brian T. Wilhelm & Gary D. Bader & Gene W. Yeo & Kristin J. Hope, 2016. "Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells," Nature, Nature, vol. 532(7600), pages 508-511, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7600:d:10.1038_nature17665
    DOI: 10.1038/nature17665
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    Cited by:

    1. Michelle M. Kameda-Smith & Helen Zhu & En-Ching Luo & Yujin Suk & Agata Xella & Brian Yee & Chirayu Chokshi & Sansi Xing & Frederick Tan & Raymond G. Fox & Ashley A. Adile & David Bakhshinyan & Kevin , 2022. "Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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