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Normalizing the environment recapitulates adult human immune traits in laboratory mice

Author

Listed:
  • Lalit K. Beura

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Sara E. Hamilton

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Kevin Bi

    (Dana-Farber Cancer Institute, and Pediatric Hematology and Oncology, Children's Hospital)

  • Jason M. Schenkel

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Oludare A. Odumade

    (Center for Immunology, University of Minnesota, Minneapolis
    † Present addresses: Department of Pediatrics, University of California San Diego, Rady Children’s Hospital, San Diego, California 92123, USA (O.A.O.); Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland 20878, USA (K.A.C.).)

  • Kerry A. Casey

    (Center for Immunology, University of Minnesota, Minneapolis
    † Present addresses: Department of Pediatrics, University of California San Diego, Rady Children’s Hospital, San Diego, California 92123, USA (O.A.O.); Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland 20878, USA (K.A.C.).)

  • Emily A. Thompson

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Kathryn A. Fraser

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Pamela C. Rosato

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Ali Filali-Mouhim

    (Case Western Reserve University)

  • Rafick P. Sekaly

    (Case Western Reserve University)

  • Marc K. Jenkins

    (Center for Immunology, University of Minnesota, Minneapolis)

  • Vaiva Vezys

    (Center for Immunology, University of Minnesota, Minneapolis)

  • W. Nicholas Haining

    (Dana-Farber Cancer Institute, and Pediatric Hematology and Oncology, Children's Hospital)

  • Stephen C. Jameson

    (Center for Immunology, University of Minnesota, Minneapolis)

  • David Masopust

    (Center for Immunology, University of Minnesota, Minneapolis)

Abstract

The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system of adult humans or 'dirty' mice by co-housing with pet store-bought mice.

Suggested Citation

  • Lalit K. Beura & Sara E. Hamilton & Kevin Bi & Jason M. Schenkel & Oludare A. Odumade & Kerry A. Casey & Emily A. Thompson & Kathryn A. Fraser & Pamela C. Rosato & Ali Filali-Mouhim & Rafick P. Sekaly, 2016. "Normalizing the environment recapitulates adult human immune traits in laboratory mice," Nature, Nature, vol. 532(7600), pages 512-516, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7600:d:10.1038_nature17655
    DOI: 10.1038/nature17655
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    Cited by:

    1. Julia D. Berkson & Claire E. Wate & Garrison B. Allen & Alyxandria M. Schubert & Kristin E. Dunbar & Michael P. Coryell & Rosa L. Sava & Yamei Gao & Jessica L. Hastie & Emily M. Smith & Charlotte R. K, 2024. "Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Ondrej Suchanek & John R. Ferdinand & Zewen K. Tuong & Sathi Wijeyesinghe & Anita Chandra & Ann-Katrin Clauder & Larissa N. Almeida & Simon Clare & Katherine Harcourt & Christopher J. Ward & Rachael B, 2023. "Tissue-resident B cells orchestrate macrophage polarisation and function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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