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Age-dependent modulation of vascular niches for haematopoietic stem cells

Author

Listed:
  • Anjali P. Kusumbe

    (Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Saravana K. Ramasamy

    (Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Tomer Itkin

    (The Weizmann Institute of Science)

  • Maarja Andaloussi Mäe

    (Vascular Biology Program, Genetics and Pathology, Uppsala University)

  • Urs H. Langen

    (Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Christer Betsholtz

    (Vascular Biology Program, Genetics and Pathology, Uppsala University
    Karolinska Institute)

  • Tsvee Lapidot

    (The Weizmann Institute of Science)

  • Ralf H. Adams

    (Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

Abstract

Notch signalling in endothelial cells of the bone induces change in the capillaries and mesenchymal stem cells of the environment to support haematopoietic stem cell amplification.

Suggested Citation

  • Anjali P. Kusumbe & Saravana K. Ramasamy & Tomer Itkin & Maarja Andaloussi Mäe & Urs H. Langen & Christer Betsholtz & Tsvee Lapidot & Ralf H. Adams, 2016. "Age-dependent modulation of vascular niches for haematopoietic stem cells," Nature, Nature, vol. 532(7599), pages 380-384, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7599:d:10.1038_nature17638
    DOI: 10.1038/nature17638
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    Cited by:

    1. Young-Woong Kim & Greta Zara & HyunJun Kang & Sergio Branciamore & Denis O’Meally & Yuxin Feng & Chia-Yi Kuan & Yingjun Luo & Michael S. Nelson & Alex B. Brummer & Russell Rockne & Zhen Bouman Chen & , 2022. "Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Joschka Heil & Victor Olsavszky & Katrin Busch & Kay Klapproth & Carolina Torre & Carsten Sticht & Kajetan Sandorski & Johannes Hoffmann & Hiltrud Schönhaber & Johanna Zierow & Manuel Winkler & Christ, 2021. "Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Alexandra N. Rindone & Xiaonan Liu & Stephanie Farhat & Alexander Perdomo-Pantoja & Timothy F. Witham & Daniel L. Coutu & Mei Wan & Warren L. Grayson, 2021. "Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    4. Christina M. Termini & Amara Pang & Tiancheng Fang & Martina Roos & Vivian Y. Chang & Yurun Zhang & Nicollette J. Setiawan & Lia Signaevskaia & Michelle Li & Mindy M. Kim & Orel Tabibi & Paulina K. Li, 2021. "Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Till Fabian Mertens & Alina Tabea Liebheit & Johanna Ehl & Ralf Köhler & Asylkhan Rakhymzhan & Andrew Woehler & Lukas Katthän & Gernot Ebel & Wjatscheslaw Liublin & Ana Kasapi & Antigoni Triantafyllop, 2024. "MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    6. Susanne Fleig & Tamar Kapanadze & Jeremiah Bernier-Latmani & Julia K. Lill & Tania Wyss & Jaba Gamrekelashvili & Dustin Kijas & Bin Liu & Anne M. Hüsing & Esther Bovay & Adan Chari Jirmo & Stephan Hal, 2022. "Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    8. Naoki Itokawa & Motohiko Oshima & Shuhei Koide & Naoya Takayama & Wakako Kuribayashi & Yaeko Nakajima-Takagi & Kazumasa Aoyama & Satoshi Yamazaki & Kiyoshi Yamaguchi & Yoichi Furukawa & Koji Eto & Ats, 2022. "Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    9. Yang Liu & Qi Chen & Hyun-Woo Jeong & Bong Ihn Koh & Emma C. Watson & Cong Xu & Martin Stehling & Bin Zhou & Ralf H. Adams, 2022. "A specialized bone marrow microenvironment for fetal haematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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