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NOD1 and NOD2 signalling links ER stress with inflammation

Author

Listed:
  • A. Marijke Keestra-Gounder

    (School of Medicine, University of California at Davis)

  • Mariana X. Byndloss

    (School of Medicine, University of California at Davis)

  • Núbia Seyffert

    (School of Medicine, University of California at Davis)

  • Briana M. Young

    (School of Medicine, University of California at Davis)

  • Alfredo Chávez-Arroyo

    (School of Medicine, University of California at Davis)

  • April Y. Tsai

    (School of Medicine, University of California at Davis)

  • Stephanie A. Cevallos

    (School of Medicine, University of California at Davis)

  • Maria G. Winter

    (School of Medicine, University of California at Davis)

  • Oanh H. Pham

    (Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis)

  • Connor R. Tiffany

    (School of Medicine, University of California at Davis)

  • Maarten F. de Jong

    (School of Medicine, University of California at Davis)

  • Tobias Kerrinnes

    (School of Medicine, University of California at Davis)

  • Resmi Ravindran

    (Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis)

  • Paul A. Luciw

    (Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis)

  • Stephen J. McSorley

    (Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis)

  • Andreas J. Bäumler

    (School of Medicine, University of California at Davis)

  • Renée M. Tsolis

    (School of Medicine, University of California at Davis)

Abstract

A novel link between the unfolded protein response and NOD1/2 innate immune signalling, showing that NOD1/2 are required for ER-stress-induced IL-6 production in response to infection with Brucella abortus.

Suggested Citation

  • A. Marijke Keestra-Gounder & Mariana X. Byndloss & Núbia Seyffert & Briana M. Young & Alfredo Chávez-Arroyo & April Y. Tsai & Stephanie A. Cevallos & Maria G. Winter & Oanh H. Pham & Connor R. Tiffany, 2016. "NOD1 and NOD2 signalling links ER stress with inflammation," Nature, Nature, vol. 532(7599), pages 394-397, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7599:d:10.1038_nature17631
    DOI: 10.1038/nature17631
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    Cited by:

    1. Xiaoyi Cheng & Radwa Barakat & Giulia Pavani & Masuma Khatun Usha & Rodolfo Calderon & Elizabeth Snella & Abigail Gorden & Yudi Zhang & Paul Gadue & Deborah L. French & Karin S. Dorman & Antonella Fid, 2023. "Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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