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Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes

Author

Listed:
  • Dilmi Perera

    (Prince of Wales Clinical School and Lowy Cancer Research Centre)

  • Rebecca C. Poulos

    (Prince of Wales Clinical School and Lowy Cancer Research Centre)

  • Anushi Shah

    (Prince of Wales Clinical School and Lowy Cancer Research Centre)

  • Dominik Beck

    (Prince of Wales Clinical School and Lowy Cancer Research Centre)

  • John E. Pimanda

    (Prince of Wales Clinical School and Lowy Cancer Research Centre
    Prince of Wales Hospital)

  • Jason W. H. Wong

    (Prince of Wales Clinical School and Lowy Cancer Research Centre)

Abstract

Analysis of 1,161 cancer genomes across 14 cancer types shows that increased mutation density at gene promoters can be linked to transcription initiation activity and impairment of nucleotide excision repair.

Suggested Citation

  • Dilmi Perera & Rebecca C. Poulos & Anushi Shah & Dominik Beck & John E. Pimanda & Jason W. H. Wong, 2016. "Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes," Nature, Nature, vol. 532(7598), pages 259-263, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17437
    DOI: 10.1038/nature17437
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    Cited by:

    1. Ye Cai & Huifen Cao & Fang Wang & Yufei Zhang & Philipp Kapranov, 2022. "Complex genomic patterns of abasic sites in mammalian DNA revealed by a high-resolution SSiNGLe-AP method," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Kathiresan Selvam & Smitha Sivapragasam & Gregory M. K. Poon & John J. Wyrick, 2023. "Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Kerryn Elliott & Vinod Kumar Singh & Martin Boström & Erik Larsson, 2023. "Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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