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The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

Author

Listed:
  • Lena Seifert

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Gregor Werba

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Shaun Tiwari

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Nancy Ngoc Giao Ly

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Sara Alothman

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Dalia Alqunaibit

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Antonina Avanzi

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Rocky Barilla

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Donnele Daley

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Stephanie H. Greco

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Alejandro Torres-Hernandez

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Matthew Pergamo

    (New York University School of Medicine)

  • Atsuo Ochi

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Constantinos P. Zambirinis

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Mridul Pansari

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Mauricio Rendon

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Daniel Tippens

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Mautin Hundeyin

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Vishnu R. Mani

    (S. Arthur Localio Laboratory, New York University School of Medicine)

  • Cristina Hajdu

    (New York University School of Medicine)

  • Dannielle Engle

    (Cold Spring Harbor Laboratories)

  • George Miller

    (S. Arthur Localio Laboratory, New York University School of Medicine
    New York University School of Medicine)

Abstract

A study of pancreatic ductal adenocarcinoma shows that cancer cell proliferation is associated with increased expression of proteins that control programmed necrotic cell death and suppress the adaptive immune system.

Suggested Citation

  • Lena Seifert & Gregor Werba & Shaun Tiwari & Nancy Ngoc Giao Ly & Sara Alothman & Dalia Alqunaibit & Antonina Avanzi & Rocky Barilla & Donnele Daley & Stephanie H. Greco & Alejandro Torres-Hernandez &, 2016. "The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression," Nature, Nature, vol. 532(7598), pages 245-249, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17403
    DOI: 10.1038/nature17403
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    Cited by:

    1. Cheng-Yu Liao & Ge Li & Feng-Ping Kang & Cai-Feng Lin & Cheng-Ke Xie & Yong-Ding Wu & Jian-Fei Hu & Hong-Yi Lin & Shun-Cang Zhu & Xiao-Xiao Huang & Jian-Lin Lai & Li-Qun Chen & Yi Huang & Qiao-Wei Li , 2024. "Necroptosis enhances ‘don’t eat me’ signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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