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sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Author

Listed:
  • Amanpreet Kaur

    (The Wistar Institute
    University of the Sciences)

  • Marie R. Webster

    (The Wistar Institute)

  • Katie Marchbank

    (The Wistar Institute)

  • Reeti Behera

    (The Wistar Institute)

  • Abibatou Ndoye

    (The Wistar Institute)

  • Curtis H. Kugel

    (The Wistar Institute)

  • Vanessa M. Dang

    (The Wistar Institute)

  • Jessica Appleton

    (The Wistar Institute)

  • Michael P. O’Connell

    (The Wistar Institute)

  • Phil Cheng

    (University of Zurich)

  • Alexander A. Valiga

    (The Wistar Institute)

  • Rachel Morissette

    (The National Institute on Aging, National Institutes of Health)

  • Nazli B. McDonnell

    (The National Institute on Aging, National Institutes of Health)

  • Luigi Ferrucci

    (The National Institute on Aging, National Institutes of Health)

  • Andrew V. Kossenkov

    (The Wistar Institute)

  • Katrina Meeth

    (Yale University)

  • Hsin-Yao Tang

    (The Wistar Institute)

  • Xiangfan Yin

    (The Wistar Institute)

  • William H. Wood

    (The National Institute on Aging, National Institutes of Health)

  • Elin Lehrmann

    (The National Institute on Aging, National Institutes of Health)

  • Kevin G. Becker

    (The National Institute on Aging, National Institutes of Health)

  • Keith T. Flaherty

    (Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA)

  • Dennie T. Frederick

    (Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA)

  • Jennifer A. Wargo

    (MD Anderson Cancer Center)

  • Zachary A. Cooper

    (MD Anderson Cancer Center)

  • Michael T. Tetzlaff

    (MD Anderson Cancer Center)

  • Courtney Hudgens

    (MD Anderson Cancer Center)

  • Katherine M. Aird

    (The Wistar Institute)

  • Rugang Zhang

    (The Wistar Institute)

  • Xiaowei Xu

    (Abramson Cancer Center, University of Pennsylvania)

  • Qin Liu

    (The Wistar Institute)

  • Edmund Bartlett

    (Abramson Cancer Center, University of Pennsylvania)

  • Giorgos Karakousis

    (Abramson Cancer Center, University of Pennsylvania)

  • Zeynep Eroglu

    (City of Hope Medical Center)

  • Roger S. Lo

    (University of California Los Angeles)

  • Matthew Chan

    (Crown Princess Mary Cancer Centre)

  • Alexander M. Menzies

    (Melanoma Institute Australia and The University of Sydney)

  • Georgina V. Long

    (Melanoma Institute Australia and The University of Sydney)

  • Douglas B. Johnson

    (Vanderbilt University Medical Center)

  • Jeffrey Sosman

    (Vanderbilt University Medical Center)

  • Bastian Schilling

    (University Hospital, West German Cancer Center, University Duesburg-Essen
    German Cancer Consortium (DKTK))

  • Dirk Schadendorf

    (University Hospital, West German Cancer Center, University Duesburg-Essen
    German Cancer Consortium (DKTK))

  • David W. Speicher

    (The Wistar Institute)

  • Marcus Bosenberg

    (Yale University)

  • Antoni Ribas

    (University of California Los Angeles)

  • Ashani T. Weeraratna

    (The Wistar Institute)

Abstract

Aged fibroblasts release a Wnt antagonist, sFRP2, which drives a signalling cascade in melanoma cells, leading to increased metastasis and reduced effectiveness of targeted therapy.

Suggested Citation

  • Amanpreet Kaur & Marie R. Webster & Katie Marchbank & Reeti Behera & Abibatou Ndoye & Curtis H. Kugel & Vanessa M. Dang & Jessica Appleton & Michael P. O’Connell & Phil Cheng & Alexander A. Valiga & R, 2016. "sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance," Nature, Nature, vol. 532(7598), pages 250-254, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17392
    DOI: 10.1038/nature17392
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    Cited by:

    1. Miranda V. Hunter & Reuben Moncada & Joshua M. Weiss & Itai Yanai & Richard M. White, 2021. "Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    2. Damien Maggiorani & Oanh Le & Véronique Lisi & Séverine Landais & Gaël Moquin-Beaudry & Vincent Philippe Lavallée & Hélène Decaluwe & Christian Beauséjour, 2024. "Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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