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Thalamic reticular impairment underlies attention deficit in Ptchd1Y/− mice

Author

Listed:
  • Michael F. Wells

    (Duke University Medical Center
    McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Ralf D. Wimmer

    (Neuroscience Institute, New York University Langone Medical Center
    New York University Langone Medical Center)

  • L. Ian Schmitt

    (Neuroscience Institute, New York University Langone Medical Center
    New York University Langone Medical Center)

  • Guoping Feng

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard)

  • Michael M. Halassa

    (Neuroscience Institute, New York University Langone Medical Center
    New York University Langone Medical Center
    New York University Langone Medical Center
    Center for Neural Science, New York University)

Abstract

Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision, and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision period, risk-seeking rats could be converted to risk-avoiding rats.

Suggested Citation

  • Michael F. Wells & Ralf D. Wimmer & L. Ian Schmitt & Guoping Feng & Michael M. Halassa, 2016. "Thalamic reticular impairment underlies attention deficit in Ptchd1Y/− mice," Nature, Nature, vol. 532(7597), pages 58-63, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7597:d:10.1038_nature17427
    DOI: 10.1038/nature17427
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