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Derivation and differentiation of haploid human embryonic stem cells

Author

Listed:
  • Ido Sagi

    (The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University)

  • Gloryn Chia

    (Columbia University)

  • Tamar Golan-Lev

    (The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University)

  • Mordecai Peretz

    (The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University)

  • Uri Weissbein

    (The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University)

  • Lina Sui

    (Columbia University)

  • Mark V. Sauer

    (Center for Women’s Reproductive Care, College of Physicians and Surgeons, Columbia University)

  • Ofra Yanuka

    (The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University)

  • Dieter Egli

    (Columbia University
    The New York Stem Cell Foundation Research Institute)

  • Nissim Benvenisty

    (The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University)

Abstract

Haploid human embryonic stem cells have been derived from haploid oocytes, the cells maintain a normal haploid karyotype as pluripotent cells and, unexpectedly, as differentiated cells — loss-of-function genetic screens previously performed with haploid embryonic stem cells in mice can now be performed in humans.

Suggested Citation

  • Ido Sagi & Gloryn Chia & Tamar Golan-Lev & Mordecai Peretz & Uri Weissbein & Lina Sui & Mark V. Sauer & Ofra Yanuka & Dieter Egli & Nissim Benvenisty, 2016. "Derivation and differentiation of haploid human embryonic stem cells," Nature, Nature, vol. 532(7597), pages 107-111, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7597:d:10.1038_nature17408
    DOI: 10.1038/nature17408
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    Cited by:

    1. Shiran Bar & Dan Vershkov & Gal Keshet & Elyad Lezmi & Naama Meller & Atilgan Yilmaz & Ofra Yanuka & Malka Nissim-Rafinia & Eran Meshorer & Talia Eldar-Geva & Nissim Benvenisty, 2021. "Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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