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Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

Author

Listed:
  • Ryu Okumura

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
    Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development)

  • Takashi Kurakawa

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University)

  • Takashi Nakano

    (Osaka Medical College)

  • Hisako Kayama

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
    Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development)

  • Makoto Kinoshita

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
    Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development)

  • Daisuke Motooka

    (Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University)

  • Kazuyoshi Gotoh

    (Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
    Okayama University Graduate School of Medicine)

  • Taishi Kimura

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University)

  • Naganori Kamiyama

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University)

  • Takashi Kusu

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University)

  • Yoshiyasu Ueda

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University)

  • Hong Wu

    (Osaka Medical College)

  • Hideki Iijima

    (Graduate School of Medicine, Osaka University)

  • Soumik Barman

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
    Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development)

  • Hideki Osawa

    (Graduate School of Medicine, Osaka University)

  • Hiroshi Matsuno

    (Graduate School of Medicine, Osaka University)

  • Junichi Nishimura

    (Graduate School of Medicine, Osaka University)

  • Yusuke Ohba

    (Hokkaido University Graduate School of Medicine)

  • Shota Nakamura

    (Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University)

  • Tetsuya Iida

    (Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
    Research Institute for Microbial Diseases, Osaka University)

  • Masahiro Yamamoto

    (Laboratory of Immunoparasitology, Research Institute for Microbial Diseases, WPI Immunology Frontier Research Center, Osaka University)

  • Eiji Umemoto

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
    Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development)

  • Koichi Sano

    (Osaka Medical College)

  • Kiyoshi Takeda

    (Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
    Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development)

Abstract

Lypd8 protein derived from intestinal epithelial cells binds to flagellated bacteria to reduce their motility, which limits the entry of Gram-negative bacteria into the inner colonic mucus and prevents invasion of colonic epithelia.

Suggested Citation

  • Ryu Okumura & Takashi Kurakawa & Takashi Nakano & Hisako Kayama & Makoto Kinoshita & Daisuke Motooka & Kazuyoshi Gotoh & Taishi Kimura & Naganori Kamiyama & Takashi Kusu & Yoshiyasu Ueda & Hong Wu & H, 2016. "Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia," Nature, Nature, vol. 532(7597), pages 117-121, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7597:d:10.1038_nature17406
    DOI: 10.1038/nature17406
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