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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

Author

Listed:
  • Edward T. Chouchani

    (Dana-Farber Cancer Institute, Harvard Medical School
    Harvard Medical School)

  • Lawrence Kazak

    (Dana-Farber Cancer Institute, Harvard Medical School
    Harvard Medical School)

  • Mark P. Jedrychowski

    (Harvard Medical School)

  • Gina Z. Lu

    (Dana-Farber Cancer Institute, Harvard Medical School
    Harvard Medical School)

  • Brian K. Erickson

    (Harvard Medical School)

  • John Szpyt

    (Harvard Medical School)

  • Kerry A. Pierce

    (Broad Institute of Harvard and MIT)

  • Dina Laznik-Bogoslavski

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Ramalingam Vetrivelan

    (Harvard Medical School)

  • Clary B. Clish

    (Broad Institute of Harvard and MIT)

  • Alan J. Robinson

    (MRC Mitochondrial Biology Unit)

  • Steve P. Gygi

    (Harvard Medical School)

  • Bruce M. Spiegelman

    (Dana-Farber Cancer Institute, Harvard Medical School
    Harvard Medical School)

Abstract

Uncoupling protein 1 (UCP1)-dependent thermogenesis in brown adipose tissue is supported by a burst of mitochondrial reactive oxygen species upon cold exposure.

Suggested Citation

  • Edward T. Chouchani & Lawrence Kazak & Mark P. Jedrychowski & Gina Z. Lu & Brian K. Erickson & John Szpyt & Kerry A. Pierce & Dina Laznik-Bogoslavski & Ramalingam Vetrivelan & Clary B. Clish & Alan J., 2016. "Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1," Nature, Nature, vol. 532(7597), pages 112-116, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7597:d:10.1038_nature17399
    DOI: 10.1038/nature17399
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    Cited by:

    1. Hang Cheng & Rajaa Sebaa & Nikita Malholtra & Baptiste Lacoste & Ziyad El Hankouri & Alexia Kirby & Nigel C. Bennett & Barry Jaarsveld & Daniel W. Hart & Glenn J. Tattersall & Mary-Ellen Harper & Matt, 2021. "Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Jiamin Qiu & Feng Yue & Peipei Zhu & Jingjuan Chen & Fan Xu & Lijia Zhang & Kun Ho Kim & Madigan M. Snyder & Nanjian Luo & Hao-wei Xu & Fang Huang & W. Andy Tao & Shihuan Kuang, 2023. "FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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