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Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

Author

Listed:
  • Wei Yang

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Yibing Bai

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Ying Xiong

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Jin Zhang

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Shuokai Chen

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Xiaojun Zheng

    (Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Xiangbo Meng

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Lunyi Li

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Jing Wang

    (MOE Key Laboratory of Protein Science, School of Life Sciences, Collaborative Innovation Center for Infectious Diseases, Tsinghua University)

  • Chenguang Xu

    (MOE Key Laboratory of Protein Science, School of Life Sciences, Collaborative Innovation Center for Infectious Diseases, Tsinghua University)

  • Chengsong Yan

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Lijuan Wang

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Catharine C. Y. Chang

    (Geisel School of Medicine at Dartmouth)

  • Ta-Yuan Chang

    (Geisel School of Medicine at Dartmouth)

  • Ti Zhang

    (Second Military Medical University)

  • Penghui Zhou

    (Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine)

  • Bao-Liang Song

    (College of Life Sciences, Wuhan University)

  • Wanli Liu

    (MOE Key Laboratory of Protein Science, School of Life Sciences, Collaborative Innovation Center for Infectious Diseases, Tsinghua University)

  • Shao-cong Sun

    (The University of Texas MD Anderson Cancer Center)

  • Xiaolong Liu

    (State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Bo-liang Li

    (State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Chenqi Xu

    (State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    School of Life Science and Technology, ShanghaiTech University)

Abstract

Modulating cholesterol metabolism can improve CD8+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane cholesterol levels, better T-cell receptor clustering and signalling, improved immunological synapse maturation, and enhanced antitumour activity in mice.

Suggested Citation

  • Wei Yang & Yibing Bai & Ying Xiong & Jin Zhang & Shuokai Chen & Xiaojun Zheng & Xiangbo Meng & Lunyi Li & Jing Wang & Chenguang Xu & Chengsong Yan & Lijuan Wang & Catharine C. Y. Chang & Ta-Yuan Chang, 2016. "Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism," Nature, Nature, vol. 531(7596), pages 651-655, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7596:d:10.1038_nature17412
    DOI: 10.1038/nature17412
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    Citations

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    Cited by:

    1. Jiacheng Lyu & Lin Bai & Yumiao Li & Xiaofang Wang & Zeya Xu & Tao Ji & Hua Yang & Zizheng Song & Zhiyu Wang & Yanhong Shang & Lili Ren & Yan Li & Aimin Zang & Youchao Jia & Chen Ding, 2024. "Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Jinsen Zhang & Rui Sun & Yingying Lyu & Chaxian Liu & Ying Liu & Yuan Feng & Minjie Fu & Peter Jih Cheng Wong & Zunguo Du & Tianming Qiu & Yi Zhang & Dongxiao Zhuang & Zhiyong Qin & Yu Yao & Wei Zhu &, 2024. "Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Shiqun Wang & Wei Yan & Lingkai Kong & Shuguang Zuo & Jingyi Wu & Chunxiao Zhu & Huaping Huang & Bohao He & Jie Dong & Jiwu Wei, 2023. "Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Venetia Bazioti & Anouk M. Rose & Sjors Maassen & Frans Bianchi & Rinse Boer & Benedek Halmos & Deepti Dabral & Emma Guilbaud & Arthur Flohr-Svendsen & Anouk G. Groenen & Alejandro Marmolejo-Garza & M, 2022. "T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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