IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v531y2016i7596d10.1038_nature17400.html
   My bibliography  Save this article

Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making

Author

Listed:
  • Kelly A. Zalocusky

    (Stanford University
    Neurosciences Program, Stanford University
    CNC Program, Stanford University)

  • Charu Ramakrishnan

    (Stanford University
    CNC Program, Stanford University)

  • Talia N. Lerner

    (Stanford University
    CNC Program, Stanford University)

  • Thomas J. Davidson

    (Stanford University
    CNC Program, Stanford University)

  • Brian Knutson

    (Stanford University)

  • Karl Deisseroth

    (Stanford University
    CNC Program, Stanford University
    Howard Hughes Medical Institute, Stanford University)

Abstract

Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision period, risk-seeking rats could be converted to risk-avoiding rats.

Suggested Citation

  • Kelly A. Zalocusky & Charu Ramakrishnan & Talia N. Lerner & Thomas J. Davidson & Brian Knutson & Karl Deisseroth, 2016. "Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making," Nature, Nature, vol. 531(7596), pages 642-646, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7596:d:10.1038_nature17400
    DOI: 10.1038/nature17400
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature17400
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature17400?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tadaaki Nishioka & Suthinee Attachaipanich & Kosuke Hamaguchi & Michael Lazarus & Alban Kerchove d’Exaerde & Tom Macpherson & Takatoshi Hikida, 2023. "Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:531:y:2016:i:7596:d:10.1038_nature17400. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.