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Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Author

Listed:
  • Dheeraj S. Roy

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Autumn Arons

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Teryn I. Mitchell

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Michele Pignatelli

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Tomás J. Ryan

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Susumu Tonegawa

    (RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

Experiments in transgenic mouse models of early Alzheimer’s disease show that the amnesia seen at this stage of the disease is probably caused by a problem with memory retrieval from the hippocampus rather than an encoding defect.

Suggested Citation

  • Dheeraj S. Roy & Autumn Arons & Teryn I. Mitchell & Michele Pignatelli & Tomás J. Ryan & Susumu Tonegawa, 2016. "Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease," Nature, Nature, vol. 531(7595), pages 508-512, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7595:d:10.1038_nature17172
    DOI: 10.1038/nature17172
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    Citations

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    Cited by:

    1. Myung Chung & Katsutoshi Imanaka & Ziyan Huang & Akiyuki Watarai & Mu-Yun Wang & Kentaro Tao & Hirotaka Ejima & Tomomi Aida & Guoping Feng & Teruhiro Okuyama, 2024. "Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Chih-Ming Wang & Chun-Yuan Wu & Chen-En Lin & Ming-Chi Hsu & Jing-Chun Lin & Chuan-Chin Huang & Ting-Yu Lien & Hsin-Kai Lin & Ting-Wei Chang & Hsueh-Cheng Chiang, 2023. "Forgotten memory storage and retrieval in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Dheeraj S. Roy & Young-Gyun Park & Minyoung E. Kim & Ying Zhang & Sachie K. Ogawa & Nicholas DiNapoli & Xinyi Gu & Jae H. Cho & Heejin Choi & Lee Kamentsky & Jared Martin & Olivia Mosto & Tomomi Aida , 2022. "Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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