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Melanoma addiction to the long non-coding RNA SAMMSON

Author

Listed:
  • Eleonora Leucci

    (Laboratory For Molecular Cancer Biology, Center for Human Genetics
    Center for the Biology of Disease, VIB)

  • Roberto Vendramin

    (Laboratory For Molecular Cancer Biology, Center for Human Genetics
    Center for the Biology of Disease, VIB)

  • Marco Spinazzi

    (Center for the Biology of Disease, VIB)

  • Patrick Laurette

    (Institut de Génétique et de Biologie Moleculaire et Cellulaire (IGBMC))

  • Mark Fiers

    (Center for the Biology of Disease, VIB)

  • Jasper Wouters

    (Laboratory of Translational Cell and Tissue Research)

  • Enrico Radaelli

    (Mouse Histopathology Core Facility, Center for the Biology of Disease)

  • Sven Eyckerman

    (Medical Biotechnology Center, VIB
    Gent University)

  • Carina Leonelli

    (Center for Medical Genetics, Gent University
    Cancer Research Institute Gent, Gent University)

  • Katrien Vanderheyden

    (Center for Medical Genetics, Gent University
    Cancer Research Institute Gent, Gent University)

  • Aljosja Rogiers

    (Laboratory For Molecular Cancer Biology, Center for Human Genetics
    Center for the Biology of Disease, VIB)

  • Els Hermans

    (Gynaecologische Oncologie, KU Leuven)

  • Pieter Baatsen

    (Center for the Biology of Disease, VIB)

  • Stein Aerts

    (Laboratory of Computational Biology, Center for Human Genetics)

  • Frederic Amant

    (Gynaecologische Oncologie, KU Leuven)

  • Stefan Van Aelst

    (Computer Science and Statistics, Gent University
    KU Leuven)

  • Joost van den Oord

    (Laboratory of Translational Cell and Tissue Research)

  • Bart de Strooper

    (Center for the Biology of Disease, VIB)

  • Irwin Davidson

    (Institut de Génétique et de Biologie Moleculaire et Cellulaire (IGBMC))

  • Denis L. J. Lafontaine

    (RNA Molecular Biology, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB))

  • Kris Gevaert

    (Medical Biotechnology Center, VIB
    Gent University)

  • Jo Vandesompele

    (Center for Medical Genetics, Gent University
    Cancer Research Institute Gent, Gent University)

  • Pieter Mestdagh

    (Center for Medical Genetics, Gent University
    Cancer Research Institute Gent, Gent University)

  • Jean-Christophe Marine

    (Laboratory For Molecular Cancer Biology, Center for Human Genetics
    Center for the Biology of Disease, VIB)

Abstract

A known oncogene, MITF, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON, is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy.

Suggested Citation

  • Eleonora Leucci & Roberto Vendramin & Marco Spinazzi & Patrick Laurette & Mark Fiers & Jasper Wouters & Enrico Radaelli & Sven Eyckerman & Carina Leonelli & Katrien Vanderheyden & Aljosja Rogiers & El, 2016. "Melanoma addiction to the long non-coding RNA SAMMSON," Nature, Nature, vol. 531(7595), pages 518-522, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7595:d:10.1038_nature17161
    DOI: 10.1038/nature17161
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    Cited by:

    1. Roberta Esposito & Andrés Lanzós & Tina Uroda & Sunandini Ramnarayanan & Isabel Büchi & Taisia Polidori & Hugo Guillen-Ramirez & Ante Mihaljevic & Bernard Mefi Merlin & Lia Mela & Eugenio Zoni & Lusin, 2023. "Tumour mutations in long noncoding RNAs enhance cell fitness," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Claudia Capparelli & Timothy J. Purwin & McKenna Glasheen & Signe Caksa & Manoela Tiago & Nicole Wilski & Danielle Pomante & Sheera Rosenbaum & Mai Q. Nguyen & Weijia Cai & Janusz Franco-Barraza & Ric, 2022. "Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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