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Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases

Author

Listed:
  • Dominik A. Herbst

    (University of Basel)

  • Roman P. Jakob

    (University of Basel)

  • Franziska Zähringer

    (University of Basel
    † Present address: F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland.)

  • Timm Maier

    (University of Basel)

Abstract

A hybrid crystal structure of Mycobacterium smegmatis mycocerosic acid synthase, a multienzyme involved in the biosynthesis of mycobacterial branched-chain fatty acids, exemplifies the organization of fully-reducing polyketide synthases.

Suggested Citation

  • Dominik A. Herbst & Roman P. Jakob & Franziska Zähringer & Timm Maier, 2016. "Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases," Nature, Nature, vol. 531(7595), pages 533-537, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7595:d:10.1038_nature16993
    DOI: 10.1038/nature16993
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    Cited by:

    1. Jialiang Wang & Xiaojie Wang & Xixi Li & LiangLiang Kong & Zeqian Du & Dandan Li & Lixia Gou & Hao Wu & Wei Cao & Xiaozheng Wang & Shuangjun Lin & Ting Shi & Zixin Deng & Zhijun Wang & Jingdan Liang, 2023. "C–N bond formation by a polyketide synthase," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Guifa Zhai & Yan Zhu & Guo Sun & Fan Zhou & Yangning Sun & Zhou Hong & Chuan Dong & Peter F. Leadlay & Kui Hong & Zixin Deng & Fuling Zhou & Yuhui Sun, 2023. "Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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