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Visualization of immediate immune responses to pioneer metastatic cells in the lung

Author

Listed:
  • Mark B. Headley

    (University of California)

  • Adriaan Bins

    (University of California
    Academic Medical Center Amsterdam)

  • Alyssa Nip

    (University of California)

  • Edward W. Roberts

    (University of California)

  • Mark R. Looney

    (University of California)

  • Audrey Gerard

    (University of California)

  • Matthew F. Krummel

    (University of California)

Abstract

Tracing the fate of circulating tumour cells by intravital two-photon lung imaging shows that tumours produce microparticles as they arrive and these migrate along the lung vasculature and are mostly taken up by interstitial myeloid cells, in a process that contributes to metastatic seeding; a minor subset of microparticles is engulfed by conventional dendritic cells, which are thought to contribute to the initiation of an anti-tumour immune response in lung-draining lymph nodes.

Suggested Citation

  • Mark B. Headley & Adriaan Bins & Alyssa Nip & Edward W. Roberts & Mark R. Looney & Audrey Gerard & Matthew F. Krummel, 2016. "Visualization of immediate immune responses to pioneer metastatic cells in the lung," Nature, Nature, vol. 531(7595), pages 513-517, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7595:d:10.1038_nature16985
    DOI: 10.1038/nature16985
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    Cited by:

    1. Hao Li & Meng Wang & Biao Huang & Su-Wen Zhu & Jun-Jie Zhou & De-Run Chen & Ran Cui & Mingxi Zhang & Zhi-Jun Sun, 2021. "Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Maria J. Garcia-Leon & Cristina Liboni & Vincent Mittelheisser & Louis Bochler & Gautier Follain & Clarisse Mouriaux & Ignacio Busnelli & Annabel Larnicol & Florent Colin & Marina Peralta & Naël Osman, 2024. "Platelets favor the outgrowth of established metastases," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Lei Xia & Anastasia Komissarova & Arielle Jacover & Yehuda Shovman & Sebastian Arcila-Barrera & Sharona Tornovsky-Babeay & Milsee Mol Jaya Prakashan & Abdelmajeed Nasereddin & Inbar Plaschkes & Yuval , 2023. "Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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