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Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons

Author

Listed:
  • A. R. Mardinly

    (University of California Berkeley)

  • I. Spiegel

    (Harvard Medical School)

  • A. Patrizi

    (FM Kirby Neurobiology Center, Boston Children’s Hospital)

  • E. Centofante

    (FM Kirby Neurobiology Center, Boston Children’s Hospital)

  • J. E. Bazinet

    (Harvard Medical School)

  • C. P. Tzeng

    (Harvard Medical School)

  • C. Mandel-Brehm

    (Harvard Medical School)

  • D. A. Harmin

    (Harvard Medical School)

  • H. Adesnik

    (University of California Berkeley)

  • M. Fagiolini

    (FM Kirby Neurobiology Center, Boston Children’s Hospital)

  • M. E. Greenberg

    (Harvard Medical School)

Abstract

Igf1 is identified in mice as an experience-induced gene that functions cell-autonomously to increase inhibitory input onto a disinhibitory subtype of GABAergic neurons in the cortex, affecting the downstream excitation–inhibition balance within circuits that regulate visual acuity, and providing a novel example of experience modulating neural plasticity.

Suggested Citation

  • A. R. Mardinly & I. Spiegel & A. Patrizi & E. Centofante & J. E. Bazinet & C. P. Tzeng & C. Mandel-Brehm & D. A. Harmin & H. Adesnik & M. Fagiolini & M. E. Greenberg, 2016. "Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons," Nature, Nature, vol. 531(7594), pages 371-375, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7594:d:10.1038_nature17187
    DOI: 10.1038/nature17187
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    Cited by:

    1. Kenneth D Harris & Hannah Hochgerner & Nathan G Skene & Lorenza Magno & Linda Katona & Carolina Bengtsson Gonzales & Peter Somogyi & Nicoletta Kessaris & Sten Linnarsson & Jens Hjerling-Leffler, 2018. "Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics," PLOS Biology, Public Library of Science, vol. 16(6), pages 1-37, June.

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