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Lens regeneration using endogenous stem cells with gain of visual function

Author

Listed:
  • Haotian Lin

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Hong Ouyang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Jie Zhu

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Shan Huang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Zhenzhen Liu

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Shuyi Chen

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Guiqun Cao

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Gen Li

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    Guangzhou KangRui Biological Pharmaceutical Technology Company)

  • Robert A. J. Signer

    (Howard Hughes Medical Institute, Children’s Research Institute, University of Texas Southwestern Medical Center)

  • Yanxin Xu

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    West China Hospital, Sichuan University)

  • Christopher Chung

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Ying Zhang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Danni Lin

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Sherrina Patel

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Frances Wu

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Huimin Cai

    (Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    Guangzhou KangRui Biological Pharmaceutical Technology Company)

  • Jiayi Hou

    (Clinical and Translational Research Institute, University of California)

  • Cindy Wen

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Maryam Jafari

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Xialin Liu

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Lixia Luo

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Jin Zhu

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Austin Qiu

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Rui Hou

    (Guangzhou KangRui Biological Pharmaceutical Technology Company)

  • Baoxin Chen

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Jiangna Chen

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • David Granet

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Christopher Heichel

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Fu Shang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Xuri Li

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • Michal Krawczyk

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Dorota Skowronska-Krawczyk

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Yujuan Wang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

  • William Shi

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Daniel Chen

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Zheng Zhong

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Sheng Zhong

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Liangfang Zhang

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Shaochen Chen

    (Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California)

  • Sean J. Morrison

    (Howard Hughes Medical Institute, Children’s Research Institute, University of Texas Southwestern Medical Center)

  • Richard L. Maas

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Kang Zhang

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California
    Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
    Veterans Administration Healthcare System)

  • Yizhi Liu

    (State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University)

Abstract

The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently, the only treatment for cataracts, the leading cause of blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular lens. However, this procedure poses notable risks of complications. Here we isolate lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal. We design a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts. Our method differs conceptually from current practice, as it preserves endogenous LECs and their natural environment maximally, and regenerates lenses with visual function. Our approach demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells.

Suggested Citation

  • Haotian Lin & Hong Ouyang & Jie Zhu & Shan Huang & Zhenzhen Liu & Shuyi Chen & Guiqun Cao & Gen Li & Robert A. J. Signer & Yanxin Xu & Christopher Chung & Ying Zhang & Danni Lin & Sherrina Patel & Fra, 2016. "Lens regeneration using endogenous stem cells with gain of visual function," Nature, Nature, vol. 531(7594), pages 323-328, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7594:d:10.1038_nature17181
    DOI: 10.1038/nature17181
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    Cited by:

    1. Yue Hong & Shan Shan & Ye Gu & Haidong Huang & Quncheng Zhang & Yang Han & Yongpin Dong & Zeyu Liu & Moli Huang & Tao Ren, 2022. "Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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