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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Author

Listed:
  • Travis K. Warren

    (United States Army Medical Research Institute of Infectious Diseases
    United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center)

  • Robert Jordan

    (Gilead Sciences)

  • Michael K. Lo

    (Centers for Disease Control and Prevention)

  • Adrian S. Ray

    (Gilead Sciences)

  • Richard L. Mackman

    (Gilead Sciences)

  • Veronica Soloveva

    (United States Army Medical Research Institute of Infectious Diseases
    United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center)

  • Dustin Siegel

    (Gilead Sciences)

  • Michel Perron

    (Gilead Sciences)

  • Roy Bannister

    (Gilead Sciences)

  • Hon C. Hui

    (Gilead Sciences)

  • Nate Larson

    (Gilead Sciences)

  • Robert Strickley

    (Gilead Sciences)

  • Jay Wells

    (United States Army Medical Research Institute of Infectious Diseases)

  • Kelly S. Stuthman

    (United States Army Medical Research Institute of Infectious Diseases)

  • Sean A. Van Tongeren

    (United States Army Medical Research Institute of Infectious Diseases)

  • Nicole L. Garza

    (United States Army Medical Research Institute of Infectious Diseases)

  • Ginger Donnelly

    (United States Army Medical Research Institute of Infectious Diseases)

  • Amy C. Shurtleff

    (United States Army Medical Research Institute of Infectious Diseases)

  • Cary J. Retterer

    (United States Army Medical Research Institute of Infectious Diseases)

  • Dima Gharaibeh

    (United States Army Medical Research Institute of Infectious Diseases)

  • Rouzbeh Zamani

    (United States Army Medical Research Institute of Infectious Diseases)

  • Tara Kenny

    (United States Army Medical Research Institute of Infectious Diseases)

  • Brett P. Eaton

    (United States Army Medical Research Institute of Infectious Diseases)

  • Elizabeth Grimes

    (United States Army Medical Research Institute of Infectious Diseases)

  • Lisa S. Welch

    (United States Army Medical Research Institute of Infectious Diseases
    †Present addresses: LOKET Consulting, Clarksburg, Maryland 20871, USA (L.S.W.); Cocrystal Pharma, Tucker, Georgia 30084, USA (D.L.M).)

  • Laura Gomba

    (United States Army Medical Research Institute of Infectious Diseases
    United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center)

  • Catherine L. Wilhelmsen

    (United States Army Medical Research Institute of Infectious Diseases)

  • Donald K. Nichols

    (United States Army Medical Research Institute of Infectious Diseases)

  • Jonathan E. Nuss

    (United States Army Medical Research Institute of Infectious Diseases
    United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center)

  • Elyse R. Nagle

    (United States Army Medical Research Institute of Infectious Diseases)

  • Jeffrey R. Kugelman

    (United States Army Medical Research Institute of Infectious Diseases)

  • Gustavo Palacios

    (United States Army Medical Research Institute of Infectious Diseases)

  • Edward Doerffler

    (Gilead Sciences)

  • Sean Neville

    (Gilead Sciences)

  • Ernest Carra

    (Gilead Sciences)

  • Michael O. Clarke

    (Gilead Sciences)

  • Lijun Zhang

    (Gilead Sciences)

  • Willard Lew

    (Gilead Sciences)

  • Bruce Ross

    (Gilead Sciences)

  • Queenie Wang

    (Gilead Sciences)

  • Kwon Chun

    (Gilead Sciences)

  • Lydia Wolfe

    (Gilead Sciences)

  • Darius Babusis

    (Gilead Sciences)

  • Yeojin Park

    (Gilead Sciences)

  • Kirsten M. Stray

    (Gilead Sciences)

  • Iva Trancheva

    (Gilead Sciences)

  • Joy Y. Feng

    (Gilead Sciences)

  • Ona Barauskas

    (Gilead Sciences)

  • Yili Xu

    (Gilead Sciences)

  • Pamela Wong

    (Gilead Sciences)

  • Molly R. Braun

    (Boston University School of Medicine)

  • Mike Flint

    (Centers for Disease Control and Prevention)

  • Laura K. McMullan

    (Centers for Disease Control and Prevention)

  • Shan-Shan Chen

    (Gilead Sciences)

  • Rachel Fearns

    (Boston University School of Medicine)

  • Swami Swaminathan

    (Gilead Sciences)

  • Douglas L. Mayers

    (United States Army Medical Research Institute of Infectious Diseases
    †Present addresses: LOKET Consulting, Clarksburg, Maryland 20871, USA (L.S.W.); Cocrystal Pharma, Tucker, Georgia 30084, USA (D.L.M).)

  • Christina F. Spiropoulou

    (Centers for Disease Control and Prevention)

  • William A. Lee

    (Gilead Sciences)

  • Stuart T. Nichol

    (Centers for Disease Control and Prevention)

  • Tomas Cihlar

    (Gilead Sciences)

  • Sina Bavari

    (United States Army Medical Research Institute of Infectious Diseases
    United States Army Medical Research Institute of Infectious Diseases, Therapeutic Development Center)

Abstract

The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of providing post-exposure therapeutic protection against lethal disease in 100% of drug-treated nonhuman primates infected with Ebola virus; the drug targets viral RNA polymerase and can distribute to sanctuary sites (such as testes, eyes and brain), suggesting that it may be able to clear persistent virus infection.

Suggested Citation

  • Travis K. Warren & Robert Jordan & Michael K. Lo & Adrian S. Ray & Richard L. Mackman & Veronica Soloveva & Dustin Siegel & Michel Perron & Roy Bannister & Hon C. Hui & Nate Larson & Robert Strickley , 2016. "Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys," Nature, Nature, vol. 531(7594), pages 381-385, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7594:d:10.1038_nature17180
    DOI: 10.1038/nature17180
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    Citations

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    Cited by:

    1. Farah Daou & Gretta Abou-Sleymane & Danielle A. Badro & Nagham Khanafer & Mansour Tobaiqy & Achraf Al Faraj, 2021. "The History, Efficacy, and Safety of Potential Therapeutics: A Narrative Overview of the Complex Life of COVID-19," IJERPH, MDPI, vol. 18(3), pages 1-16, January.
    2. Ropo E. Ogunsakin & Oluwakemi Ebenezer & Maryam A. Jordaan & Michael Shapi & Themba G. Ginindza, 2022. "Mapping Scientific Productivity Trends and Hotspots in Remdesivir Research Publications: A Bibliometric Study from 2016 to 2021," IJERPH, MDPI, vol. 19(14), pages 1-22, July.
    3. Katja Voit & Cristian Timmermann & Florian Steger, 2021. "Medication of Hydroxychloroquine, Remdesivir and Convalescent Plasma during the COVID-19 Pandemic in Germany—An Ethical Analysis," IJERPH, MDPI, vol. 18(11), pages 1-16, May.
    4. Jade Mitchell & Kara Dean & Charles Haas, 2020. "Ebola Virus Dose Response Model for Aerosolized Exposures: Insights from Primate Data," Risk Analysis, John Wiley & Sons, vol. 40(11), pages 2390-2398, November.

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